Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | CASP3 | P42574 | 1/20 | 0.57 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2281973 | 0.85 | NPC1 (0.57) | MEN1KMT2ANPC1RAB9ACASP3 | |
| SCHEMBL16560481 | 0.76 | ALDH1A1 (0.66) | MEN1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL13825372 | 0.76 | MEN1 (0.49) | MEN1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL29459415 | 0.75 | LMNA (0.65) | MEN1KMT2ANPC1RAB9ACASP3 | |
| SCHEMBL154708 | 0.75 | LMNA (0.65) | MEN1KMT2ANPC1RAB9ACASP3 | |
| SCHEMBL5049280 | 0.74 | MAPT (0.55) | MEN1KMT2AMAPTALDH1A1MAPK1 | |
| SCHEMBL21451034 | 0.74 | MEN1 (0.59) | MEN1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL26604309 | 0.74 | MEN1 (0.59) | MEN1KMT2ANPC1RAB9ACASP3 | |
| SCHEMBL6343638 | 0.74 | MAPT (0.55) | MEN1KMT2AMAPTALDH1A1MAPK1 | |
| SCHEMBL3465063 | 0.74 | MEN1 (0.69) | MEN1KMT2ANPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0674636-B1 | QUINUCLIDINE DERIVATIVES AS SQUALENE SYNTHASE INHIBITORS | ZENECA LTD (GB) | 1998-05-20 | — | — | EP | disclosed |
| EP-0674636-A1 | QUINUCLIDINE DERIVATIVES AS SQUALENE SYNTHASE INHIBITORS | ZENECA LIMITED (GB) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994014804-A1 | QUINUCLIDINE DERIVATIVES AS SQUALENE SYNTHASE INHIBITORS | ZENECA LIMITED (GB) | 1994-07-07 | — | — | WO | disclosed |