Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.61 |
| ▸ | DRD4 | P21917 | 3/20 | 0.61 |
| ▸ | DRD3 | P35462 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | CCR3 | P51677 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | CCR8 | P51685 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6543289 | 0.77 | OPRL1 (0.55) | DRD3LMNAPOLBCCR3SMN1; SMN2 | |
| SCHEMBL8553033 | 0.76 | DRD2 (0.70) | DRD2DRD4DRD3LMNAPOLB | |
| SCHEMBL8591800 | 0.76 | CHRM2 (0.53) | DRD2DRD4DRD3LMNAPOLB | |
| SCHEMBL1682046 | 0.76 | CCR3 (0.59) | DRD2DRD4DRD3LMNAPOLB | |
| SCHEMBL8624562 | 0.76 | LMNA (0.51) | DRD2DRD4DRD3LMNAPOLB | |
| SCHEMBL8623218 | 0.76 | MAPK1 (0.54) | DRD2DRD4DRD3LMNAPOLB | |
| Hydrochloric Acid SCHEMBL8551795 | 0.75 | DRD2 (0.68) | DRD2DRD4DRD3LMNAPOLB | |
| Bromide SCHEMBL1681757 | 0.75 | CCR3 (0.58) | DRD2DRD4DRD3LMNAPOLB | |
| SCHEMBL3899209 | 0.74 | CCR3 (0.68) | DRD2DRD4DRD3POLBCCR3 | |
| SCHEMBL13149349 | 0.73 | KDM4E (0.78) | LMNASMN1; SMN2SIGMAR1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0871613-A1 | BENZYL PIPERIDINE DERIVATIVES AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 1998-10-21 | — | — | EP | disclosed |
| WO-1996035666-A1 | BENZYL PIPERIDINE DERIVATIVES AS PHARMACEUTICAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 1996-11-14 | — | — | WO | disclosed |