Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MARK3 | P27448 | 1/20 | 0.32 |
| ▸ | MARK4 | Q96L34 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | STAT3 | P40763 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8625791 | 1.00 | ALDH1A1 (0.33) | ALDH1A1POLBMARK3MARK4OPRL1 | |
| SCHEMBL8562486 | 0.74 | CYP3A4 (0.33) | CA12CA1CA2CA9CA14 | |
| SCHEMBL8629913 | 0.71 | CA12 (0.31) | CA12CA1CA2CA9 | |
| SCHEMBL8623666 | 0.69 | L3MBTL1 (0.35) | ALDH1A1CA12CA1CA2CA9 | |
| SCHEMBL8624375 | 0.67 | GRIA2 (0.56) | ALDH1A1HPGDKDM4E | |
| SCHEMBL8627047 | 0.67 | GRIA2 (0.56) | ALDH1A1HPGDKDM4E | |
| SCHEMBL27383326 | 0.66 | OPRL1 (0.39) | ALDH1A1OPRL1OPRM1OPRK1 | |
| SCHEMBL8623456 | 0.63 | KDM4E (0.35) | ALDH1A1OPRL1OPRM1OPRK1CACNA1B | |
| SCHEMBL8626885 | 0.62 | KDM4C (0.33) | ALDH1A1OPRL1CACNA1BRPS6KA5KDM4E | |
| SCHEMBL27490066 | 0.61 | CA12 (0.37) | ALDH1A1POLBCA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618209-B1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1998-12-23 | — | — | EP | disclosed |
| EP-0618209-A1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1994-10-05 | — | — | EP | disclosed |