Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 5/20 | 0.36 |
| ▸ | MMP13 | P45452 | 5/20 | 0.36 |
| ▸ | THRA | P10827 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 5/20 | 0.32 |
| ▸ | TP53 | P04637 | 4/20 | 0.32 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.31 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8625009 | 0.86 | MMP12 (0.37) | MMP12MMP13THRATHRBHIF1A | |
| SCHEMBL8623584 | 0.86 | THRA (0.49) | MMP12MMP13THRATHRBHIF1A | |
| SCHEMBL8617759 | 0.85 | HSPD1 (0.37) | MMP12MMP13HIF1AMAPTTP53 | |
| SCHEMBL8624288 | 0.78 | HSPD1 (0.39) | MMP12MMP13HIF1AMAPTTP53 | |
| SCHEMBL8624417 | 0.77 | THRA (0.48) | THRATHRB | |
| SCHEMBL8623799 | 0.76 | MAPT (0.45) | PTPN1MAPTTP53HSPD1HSPE1 | |
| SCHEMBL8624230 | 0.72 | THRA (0.48) | MMP12MMP13THRATHRBMAPT | |
| SCHEMBL8666536 | 0.71 | MAPT (0.34) | MMP12MMP13HIF1AMAPTTP53 | |
| SCHEMBL8625007 | 0.69 | THRB (0.34) | MMP12MMP13THRATHRBHIF1A | |
| SCHEMBL8622615 | 0.67 | MAPT (0.40) | MMP12THRBMAPTTP53POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5854282-A | 3-benzoyl benzofuran derivatives as thyroid hormone antagonists | KARO BIO AB (SE) | 1998-12-29 | — | — | US | disclosed |
| EP-0775129-B1 | 3-BENZOYL BENZOFURAN DERIVATIVES AS THYROID HORMONE ANTAGONISTS | KAROBIO AB (SE) | 1998-10-21 | — | — | EP | disclosed |