Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NADK | O95544 | 2/20 | 0.57 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.51 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.51 |
| ▸ | HSPA5 | P11021 | 2/20 | 0.50 |
| ▸ | HSPA8 | P11142 | 2/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3704527 | 1.00 | NADK (0.57) | NADKADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL8623943 | 0.88 | NADK (0.53) | NADKADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL8623937 | 0.88 | NADK (0.53) | NADKADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL14034324 | 0.87 | AMD1 (0.55) | ADORA2AADORA3HSPA5HSPA8RXFP1 | |
| SCHEMBL19680323 | 0.86 | AHCY (0.55) | ADORA2AADORA3HSPA5HSPA8PDE4A | |
| SCHEMBL29328694 | 0.84 | HSPA8 (0.48) | ADORA2AADORA3HSPA5HSPA8LMNA | |
| SCHEMBL2582785 | 0.83 | HSPA5 (0.47) | ADORA2AADORA3HSPA5HSPA8LMNA | |
| SCHEMBL28542518 | 0.80 | ALDH1A1 (0.45) | NADKTSHRLMNAMAPTPMP22 | |
| SCHEMBL20419168 | 0.80 | CDK2 (0.49) | HSPA8HIF1A | |
| SCHEMBL20419165 | 0.80 | RAPGEF3 (0.49) | NADKADORA2AADORA1ADORA3ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150025031-A1 | METABOLIC DOWNREGULATION FOR CELL SURVIVAL | WAKE FOREST UNIVERSITY HEALTH SCIENCES | 2015-01-22 | — | — | US | claimed |
| WO-2013134209-A1 | METABOLIC DOWNREGULATION FOR CELL SURVIVAL | WAKE FOREST UNIVERSITY HEALTH SCIENCES (US) | 2013-09-12 | — | — | WO | claimed |
| JP-63159392-A | — | — | None | — | — | JP | disclosed |
| US-20210338706-A1 | ADENOSINE ANALOG AND ITS USE IN REGULATING THE CIRCADIAN CLOCK | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-11-04 | — | — | US | disclosed |
| WO-2018133854-A1 | ADENOSINE ANALOG AND ITS USE IN REGULATING THE CIRCADIAN CLOCK | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2018-07-26 | — | — | WO | disclosed |
| US-20150025031-A1 | METABOLIC DOWNREGULATION FOR CELL SURVIVAL | WAKE FOREST UNIVERSITY HEALTH SCIENCES | 2015-01-22 | — | — | US | disclosed |
| WO-2013134209-A1 | METABOLIC DOWNREGULATION FOR CELL SURVIVAL | WAKE FOREST UNIVERSITY HEALTH SCIENCES (US) | 2013-09-12 | — | — | WO | disclosed |
| US-20100009934-A1 | BETA ADRENERGIC RECEPTOR AGONISTS FOR THE TREATMENT OF B-CELL PROLIFERATIVE DISORDERS | COMBINATORX, INCORPORATED (US) | 2010-01-14 | — | — | US | disclosed |
| US-7642086-B2 | Labeled probe bound object, method for producing the same and method for using the same | CANON KABUSHIKI KAISHA (JP) | 2010-01-05 | — | — | US | disclosed |
| US-20090053168-A1 | TREATMENTS OF B-CELL PROLIFERATIVE DISORDERS | ZALICUS INC. | 2009-02-26 | — | — | US | disclosed |
| US-20090047243-A1 | COMBINATIONS FOR THE TREATMENT OF B-CELL PROLIFERATIVE DISORDERS | ZALICUS INC. | 2009-02-19 | — | — | US | disclosed |
| US-20070092897-A1 | Labeled probe bound object, method for producing the same and method for using the same | CANON KABUSHIKI KAISHA (JP) | 2007-04-26 | — | — | US | disclosed |
| EP-1276881-B1 | METHODS FOR ENHANCING THE EXPRESSION OF A PROTEIN OF INTEREST BY RECOMBINANT HOST CELLS | ZYMOGENETICS INC (US) | 2006-02-22 | — | — | EP | disclosed |
| US-6908751-B2 | Methods for enhancing the expression of a protein of interest by recombinant host cells | ZYMOGENETICS, INC. (US) | 2005-06-21 | — | — | US | disclosed |
| EP-1519189-A1 | METHOD OF ANALYZING PROBE SUPPORT BY USING FLYING TIME SECONDARY ION MASS SPECTROMETRY | CANON KABUSHIKI KAISHA (JP) | 2005-03-30 | — | — | EP | disclosed |
| US-20040137491-A1 | Method of analyzing probe carrier using time-of-flight secondary ion mass spectrometry | CANON KABUSHIKI KAISHA (JP) | 2004-07-15 | — | — | US | disclosed |
| EP-1276881-A2 | METHODS FOR ENHANCING THE EXPRESSION OF A PROTEIN OF INTEREST BY RECOMBINANT HOST CELLS | ZymoGenetics, Inc. (US) | 2003-01-22 | — | — | EP | disclosed |
| US-20020019049-A1 | Methods for enhancing the expression of a protein of interest by recombinant host cells | ZYMOGENETICS, INC. | 2002-02-14 | — | — | US | disclosed |
| WO-2001081596-A2 | METHODS FOR ENHANCING THE EXPRESSION OF A PROTEIN OF INTEREST BY RECOMBINANT HOST CELLS | ZYMOGENETICS, INC. (US) | 2001-11-01 | — | — | WO | disclosed |
| JP-S63159392-A | 8-SUBSTITUTED CORDYCEPIN AND PRODUCTION THEREOF | KIKKOMAN CORP | 1988-07-02 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090047243-A1 | COMBINATIONS FOR THE TREATMENT OF B-CELL PROLIFERATIVE DISORDERS | ADORA2A, PDE4A, PDE4D | NADK 1297/4885ADORA2A 1/4885ADORA1 31/4885 |
| US-20100009934-A1 | BETA ADRENERGIC RECEPTOR AGONISTS FOR THE TREATMENT OF B-CELL PROLIFERATIVE DISORDERS | ADRB1, ADRB2, ADRA2B | NADK 2540/4885ADORA2A 10/4885ADORA1 14/4885 |
| US-20210338706-A1 | ADENOSINE ANALOG AND ITS USE IN REGULATING THE CIRCADIAN CLOCK | PER2, CRY1, ADORA2A | NADK 827/4885ADORA2A 3/4885ADORA1 6/4885 |
| US-20090053168-A1 | TREATMENTS OF B-CELL PROLIFERATIVE DISORDERS | BCL6, BCL6B, BCL3 | NADK 1124/4885ADORA2A 9/4885ADORA1 83/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.