Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 3/20 | 0.43 |
| ▸ | THRA | P10827 | 2/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 5/20 | 0.37 |
| ▸ | EYA3 | Q99504 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.36 |
| ▸ | TTR | P02766 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.34 |
| ▸ | EYA2 | O00167 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.34 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ALB | P02768 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8621007 | 0.86 | NR1H4 (0.36) | THRBTHRANR1H4SLC22A12EYA3 | |
| SCHEMBL8621568 | 0.82 | THRA (0.47) | THRBTHRANR1H4PTPN1TTR | |
| SCHEMBL8618893 | 0.79 | THRA (0.56) | THRBTHRAEYA3CYP2C9SIRT3 | |
| SCHEMBL8620714 | 0.77 | THRA (0.45) | THRBTHRASIRT3ABCB11ESR1 | |
| SCHEMBL8625157 | 0.73 | THRA (0.77) | THRBTHRAEYA3CYP2C9SIRT3 | |
| SCHEMBL8619759 | 0.73 | HTT (0.35) | THRBTHRANR1H4SLC22A12EYA3 | |
| SCHEMBL8624484 | 0.71 | PTPN1 (0.47) | THRBTHRANR1H4SLC22A12EYA3 | |
| SCHEMBL8620047 | 0.70 | THRA (0.39) | THRBTHRANR1H4SLC22A12EYA3 | |
| SCHEMBL8618728 | 0.69 | MAPT (0.39) | THRBSLC22A12PTPN1ALDH1A1CYP1A2 | |
| SCHEMBL6344860 | 0.68 | NR1H4 (0.61) | THRBTHRANR1H4SLC22A12EYA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5854282-A | 3-benzoyl benzofuran derivatives as thyroid hormone antagonists | KARO BIO AB (SE) | 1998-12-29 | — | — | US | disclosed |
| EP-0775129-B1 | 3-BENZOYL BENZOFURAN DERIVATIVES AS THYROID HORMONE ANTAGONISTS | KAROBIO AB (SE) | 1998-10-21 | — | — | EP | disclosed |