Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | THRA | P10827 | 4/20 | 0.32 |
| ▸ | THRB | P10828 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.32 |
| ▸ | EYA3 | Q99504 | 1/20 | 0.32 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.31 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8621007 | 0.86 | NR1H4 (0.36) | LMNANR1H4THRATHRBSLC22A12 | |
| SCHEMBL8621568 | 0.85 | THRA (0.47) | NR1H4THRATHRB | |
| SCHEMBL8617962 | 0.79 | THRA (0.52) | HTTLMNACA12CA9MAPK1 | |
| SCHEMBL8618728 | 0.79 | MAPT (0.39) | HTTNPC1RAB9ATHRBMAPT | |
| SCHEMBL8619761 | 0.74 | PTPN1 (0.42) | HTTLMNACA12CA9NR1H4 | |
| SCHEMBL8624478 | 0.73 | THRB (0.43) | LMNANR1H4MAPK1THRATHRB | |
| SCHEMBL8623723 | 0.72 | EYA3 (0.56) | HTTLMNACA12CA9NR1H4 | |
| SCHEMBL8620047 | 0.71 | THRA (0.39) | LMNANR1H4THRATHRBSLC22A12 | |
| SCHEMBL8621630 | 0.71 | THRA (0.53) | HTTLMNAMAPK1TDP1THRA | |
| SCHEMBL8624371 | 0.70 | HTT (0.63) | HTTLMNACA12CA9MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5854282-A | 3-benzoyl benzofuran derivatives as thyroid hormone antagonists | KARO BIO AB (SE) | 1998-12-29 | — | — | US | disclosed |
| EP-0775129-B1 | 3-BENZOYL BENZOFURAN DERIVATIVES AS THYROID HORMONE ANTAGONISTS | KAROBIO AB (SE) | 1998-10-21 | — | — | EP | disclosed |
| EP-0775129-A1 | 3-BENZOYL BENZOFURAN DERIVATIVES AS THYROID HORMONE ANTAGONISTS | KARO BIO AB (SE) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996005190-A1 | 3-BENZOYL BENZOFURAN DERIVATIVES AS THYROID HORMONE ANTAGONISTS | KARO BIO AB (SE) | 1996-02-22 | — | — | WO | disclosed |