Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 4/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.37 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.37 |
| ▸ | KDM4A | O75164 | 3/20 | 0.36 |
| ▸ | KDM5A | P29375 | 3/20 | 0.36 |
| ▸ | ING2 | Q9H160 | 1/20 | 0.36 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8621630 | 0.86 | THRA (0.53) | THRATHRBSIRT3SMPD1KDM4A | |
| SCHEMBL8619759 | 0.85 | HTT (0.35) | THRATHRBNR1H4 | |
| SCHEMBL8624478 | 0.82 | THRB (0.43) | THRATHRBTTRPTPN1SIRT3 | |
| SCHEMBL8620714 | 0.79 | THRA (0.45) | THRATHRBSIRT3 | |
| SCHEMBL8619555 | 0.76 | TTR (0.69) | THRATHRBTTRPTPN1SIRT3 | |
| SCHEMBL4891172 | 0.75 | EYA3 (0.57) | THRATHRBTTRPTPN1SIRT3 | |
| SCHEMBL4274820 | 0.75 | CA12 (0.48) | TTRPTPN1 | |
| SCHEMBL811950 | 0.74 | CA12 (0.47) | THRATHRBTTRPTPN1 | |
| SCHEMBL8621571 | 0.74 | TTR (0.48) | THRATHRBTTRPTPN1SIRT3 | |
| SCHEMBL4279914 | 0.74 | EYA3 (0.50) | THRATHRBTTRPTPN1SIRT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5854282-A | 3-benzoyl benzofuran derivatives as thyroid hormone antagonists | KARO BIO AB (SE) | 1998-12-29 | — | — | US | disclosed |
| EP-0775129-B1 | 3-BENZOYL BENZOFURAN DERIVATIVES AS THYROID HORMONE ANTAGONISTS | KAROBIO AB (SE) | 1998-10-21 | — | — | EP | disclosed |