Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | CES2 | O00748 | 2/20 | 0.47 |
| ▸ | CES1 | P23141 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.45 |
| ▸ | FEN1 | P39748 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8625834 | 0.81 | ERCC5 (0.46) | POLBALDH1A1KMT2AERCC5FEN1 | |
| SCHEMBL8631653 | 0.79 | CTSD (0.53) | TSHRHPGDMAPTRAB9ALMNA | |
| SCHEMBL4707495 | 0.78 | CES2 (0.54) | POLBCES2CES1ALDH1A1KMT2A | |
| SCHEMBL10717928 | 0.78 | ERCC5 (0.44) | POLBCES2CES1ALDH1A1KMT2A | |
| SCHEMBL3198121 | 0.74 | TSHR (0.52) | POLBCES2CES1ALDH1A1KMT2A | |
| SCHEMBL28100608 | 0.74 | CES2 (0.48) | POLBCES2CES1ALDH1A1KMT2A | |
| SCHEMBL852910 | 0.74 | PTGDR2 (0.46) | POLBKMT2ACYP2C19 | |
| SCHEMBL30488606 | 0.74 | LMNA (0.61) | POLBCES2CES1ALDH1A1KMT2A | |
| SCHEMBL196555 | 0.74 | LMNA (0.61) | POLBCES2CES1ALDH1A1KMT2A | |
| SCHEMBL17952651 | 0.73 | KMT2A (0.57) | POLBALDH1A1KMT2AMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0646570-B1 | PROCESS FOR PRODUCING LIGNAN COMPOUND | SHIONOGI & CO (JP) | 1998-06-24 | — | — | EP | disclosed |
| US-5488134-A | Preparation of compounds of lignan series | SHIONOGI & CO., LTD. (JP) | 1996-01-30 | — | — | US | disclosed |
| EP-0646570-A1 | PROCESS FOR PRODUCING LIGNAN COMPOUND | SHIONOGI & CO., LTD. (JP) | 1995-04-05 | — | — | EP | disclosed |