SCHEMBL8626516

SCHEMBL8626516

C=CCc1ccc2c([N+](=O)[O-])c(CC=C)ccc2c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 4/20 0.39
ESR1 P03372 1/20 0.37
ESR2 Q92731 1/20 0.37
XDH P47989 1/20 0.36
MAPT P10636 4/20 0.36
CYP1A2 P05177 2/20 0.36
ALDH1A1 P00352 6/20 0.35
GABRA1 P14867 4/20 0.35
GABRB2 P47870 4/20 0.35
HTT P42858 1/20 0.35
CNR2 P34972 3/20 0.35
MEN1 O00255 3/20 0.35
GAA P10253 3/20 0.35
KMT2A Q03164 3/20 0.35
CNR1 P21554 2/20 0.35
HPGD P15428 2/20 0.35
PPARG P37231 2/20 0.35
PPARD Q03181 2/20 0.35
KDM4E B2RXH2 1/20 0.35
ALDH2 P05091 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6263856 0.81 TSHR (0.53) CYP3A4MAPTALDH1A1HTTMEN1
SCHEMBL10766133 0.72 TDP1 (0.53) MAPTALDH1A1MEN1GAAKMT2A
SCHEMBL11789708 0.72 ALDH1A1 (0.44) CYP3A4XDHMAPTCYP1A2ALDH1A1
SCHEMBL11172226 0.71 ALDH1A1 (0.47) CYP3A4MAPTALDH1A1GABRA1GABRB2
SCHEMBL11129605 0.70 TXNRD1 (0.40) CYP3A4MAPTCYP1A2ALDH1A1GABRA1
SCHEMBL3220497 0.70 XDH (0.43) CYP3A4XDHMAPTCYP1A2ALDH1A1
SCHEMBL3259762 0.70 XDH (0.58) CYP3A4XDHMAPTCYP1A2ALDH1A1
SCHEMBL28308673 0.70 ALDH1A1 (0.37) CYP3A4XDHMAPTCYP1A2ALDH1A1
SCHEMBL30083985 0.68 ALDH1A1 (0.48) CYP3A4XDHMAPTCYP1A2ALDH1A1
SCHEMBL16487290 0.68 ALDH1A1 (0.48) CYP3A4XDHMAPTCYP1A2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5795971-A FOR PAPER, CELLULOSE BAYER AKTIENGESELLSCHAFT (DE) 1998-08-18 US disclosed