SCHEMBL16487290

SCHEMBL16487290

C=CCc1ccc2c(ccc3ccccc32)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.48
HSD17B10 Q99714 2/20 0.48
CYP1B1 Q16678 2/20 0.48
HIF1A Q16665 1/20 0.48
HPRT1 P00492 3/20 0.46
AKR1B1 P15121 2/20 0.45
CYP2A6 P11509 2/20 0.44
TSHR P16473 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
XDH P47989 1/20 0.44
MAPT P10636 3/20 0.43
PPARG P37231 2/20 0.43
PPARD Q03181 2/20 0.43
HPGD P15428 2/20 0.43
KDM4E B2RXH2 1/20 0.43
MEN1 O00255 1/20 0.43
ALDH2 P05091 1/20 0.43
GAA P10253 1/20 0.43
GABRA1 P14867 1/20 0.43
CNR1 P21554 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30083985 1.00 ALDH1A1 (0.48) ALDH1A1HSD17B10CYP1B1HIF1AHPRT1
SCHEMBL16487341 0.91 ALDH1A1 (0.50) ALDH1A1HSD17B10CYP1B1HIF1AHPRT1
SCHEMBL11709613 0.90 AKR1B1 (0.59) ALDH1A1HSD17B10CYP1B1HIF1AHPRT1
SCHEMBL621971 0.84 CYP1A2 (0.54) ALDH1A1AKR1B1CYP2A6TSHRXDH
SCHEMBL31195248 0.84 CYP1A2 (0.54) ALDH1A1AKR1B1CYP2A6TSHRXDH
SCHEMBL4563164 0.82 XDH (0.48) ALDH1A1HSD17B10HIF1AAKR1B1CYP2A6
SCHEMBL1116335 0.82 XDH (0.48) ALDH1A1HSD17B10HIF1AAKR1B1CYP2A6
Bromide SCHEMBL28224561 0.82 CYP1A2 (0.52) ALDH1A1AKR1B1CYP2A6TSHRXDH
SCHEMBL3220497 0.80 XDH (0.43) ALDH1A1HSD17B10AKR1B1XDHMAPT
SCHEMBL3259762 0.80 XDH (0.58) ALDH1A1AKR1B1CYP2A6TSHRTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260003210-A1 DIFFRACTIVE CONTACT LENSES ALCON INC (CH) 2026-01-01 US claimed
US-12379611-B2 Diffractive contact lenses ALCON INC. (CH) 2025-08-05 US claimed
EP-4356169-A1 MULTIFOCAL DIFFRACTIVE SILICONE HYDROGEL CONTACT LENSES Alcon Inc. (CH) 2024-04-24 EP claimed
CN-117280252-A Multifocal diffractive silicone hydrogel contact lenses 爱尔康公司 2023-12-22 CN claimed
US-20230004023-A1 DIFFRACTIVE CONTACT LENSES ALCON INC. (CH) 2023-01-05 US claimed
WO-2022263994-A1 MULTIFOCAL DIFFRACTIVE SILICONE HYDROGEL CONTACT LENSES ALCON INC. (CH) 2022-12-22 WO claimed
WO-2026105013-A1 CONTACT LENSES WITH COLOR FILTERING ZONE ALCON INC. (CH) 2026-05-21 WO disclosed
US-20260133439-A1 CONTACT LENSES WITH COLOR FILTERING ZONE ALCON INC. (CH) 2026-05-14 US disclosed
US-20260118700-A1 DIFFRACTIVE MULTIFOCAL CONTACT LENS ALCON INC (CH) 2026-04-30 US disclosed
US-20260104598-A1 COMPOSITE CONTACT LENSES WITH ULTRATHIN OBJECTS ALCON INC (CH) 2026-04-16 US disclosed
EP-4719750-A1 EMBEDDED HYDROGEL CONTACT LENSES Alcon Inc. (CH) 2026-04-08 EP disclosed
EP-4719751-A1 METHOD FOR MAKING EMBEDDED HYDROGEL CONTACT LENSES Alcon Inc. (CH) 2026-04-08 EP disclosed
EP-4719753-A1 METHOD FOR MAKING EMBEDDED HYDROGEL CONTACT LENSES Alcon Inc. (CH) 2026-04-08 EP disclosed
CN-117280252-A Multifocal diffractive silicone hydrogel contact lenses 爱尔康公司 2023-12-22 CN disclosed
CN-116888193-A Polysiloxane vinyl cross-linking agent with high refractive index 爱尔康公司 2023-10-13 CN disclosed
US-20230004023-A1 DIFFRACTIVE CONTACT LENSES ALCON INC. (CH) 2023-01-05 US disclosed
WO-2022263994-A1 MULTIFOCAL DIFFRACTIVE SILICONE HYDROGEL CONTACT LENSES ALCON INC. (CH) 2022-12-22 WO disclosed
WO-2022201013-A1 POLYSILOXANE VINYLIC CROSSLINKERS WITH HIGH REFRACTIVE INDEX ALCON INC. (CH) 2022-09-29 WO disclosed
US-20220306810-A1 POLYSILOXANE VINYLIC CROSSLINKERS WITH HIGH REFRACTIVE INDEX ALCON INC. (CH) 2022-09-29 US disclosed
WO-2015023001-A1 NOVEL ORGANOPOLYSILOXANE, SURFACE TREATMENT AGENT COMPRISING THE SAME, RESIN COMPOSITION COMPRISING THE SAME, AND GELATINOUS PRODUCT OR CURED PRODUCT THEREOF DOW CORNING TORAY CO., LTD. (JP) 2015-02-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260133439-A1 CONTACT LENSES WITH COLOR FILTERING ZONE MYO1G, STRA6, GJA1 ALDH1A1 2727/4885HSD17B10 2996/4885CYP1B1 1369/4885
US-20260003210-A1 DIFFRACTIVE CONTACT LENSES LBR, CRYZ, CRYAA ALDH1A1 1323/4885HSD17B10 3823/4885CYP1B1 3812/4885
US-20260104598-A1 COMPOSITE CONTACT LENSES WITH ULTRATHIN OBJECTS CRYZ, CRYAA, LIMA1 ALDH1A1 1922/4885HSD17B10 3590/4885CYP1B1 3404/4885
US-20260118700-A1 DIFFRACTIVE MULTIFOCAL CONTACT LENS DSG1, SDC1, DSP ALDH1A1 3575/4885HSD17B10 3824/4885CYP1B1 2598/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.