Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.61 |
| ▸ | RAB9A | P51151 | 4/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | FAAH | O00519 | 14/20 | 0.56 |
| ▸ | CASP1 | P29466 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.50 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14977147 | 0.81 | L3MBTL1 (0.62) | L3MBTL1GAAS1PR1S1PR3 | |
| SCHEMBL14977426 | 0.81 | L3MBTL1 (0.62) | L3MBTL1GAAS1PR1S1PR3 | |
| SCHEMBL8594796 | 0.81 | L3MBTL1 (0.62) | L3MBTL1GAAS1PR1S1PR3 | |
| SCHEMBL14977512 | 0.81 | L3MBTL1 (0.62) | L3MBTL1GAAS1PR1S1PR3 | |
| SCHEMBL12411578 | 0.80 | RAB9A (0.69) | NPC1RAB9ASMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL7564852 | 0.80 | RAB9A (0.79) | NPC1RAB9ASMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL16374712 | 0.79 | NPC1 (0.69) | NPC1RAB9ASMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL27887839 | 0.79 | FAAH (0.67) | NPC1RAB9AHPGDL3MBTL1FAAH | |
| SCHEMBL9702872 | 0.78 | FAAH (0.69) | FAAH | |
| SCHEMBL21059248 | 0.78 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2HPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5927283-A | TREATING DISEASES INVOLVING OXYGEN DEFICIENCY, IN WOUND HEALING, AND IN RESTORING OXYGEN AFFINITY OF STORED BLOOD. | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1999-07-27 | — | — | US | disclosed |
| US-5872282-A | MAINTAIN OXYGEN AFFINITY IN BLOOD WHEN STORED | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1999-02-16 | — | — | US | disclosed |
| US-5731454-A | Allosteric modifiers of hemoglobin useful for decreasing oxygen affinity and preserving oxygen carrying capability of stored blood | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1998-03-24 | — | — | US | disclosed |
| US-5705521-A | Use of allosteric hemoglobin modifiers in combination with radiation therapy to treat carcinogenic tumors | THE CENTER FOR INNOVATIVE TECHNOLOGY (US) | 1998-01-06 | — | — | US | disclosed |
| US-5677330-A | THERAPY HYPOXIA, HYPOTHERMIA, ISCHEMIC, WOUNDS, ULCERS, TISSUE TRANSPLANTS, SESPIS | THE CENTER FOR INNOVATIVE TECHNOLOGY (US) | 1997-10-14 | — | — | US | disclosed |