Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 4/20 | 0.48 |
| ▸ | DRD2 | P14416 | 3/20 | 0.48 |
| ▸ | DRD3 | P35462 | 3/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8633681 | 0.89 | RECQL (0.50) | DRD4DRD2DRD3L3MBTL1HTR1A | |
| SCHEMBL8631570 | 0.87 | MAPT (0.47) | DRD4DRD2DRD3SLC6A2SLC6A4 | |
| SCHEMBL8629425 | 0.87 | DRD4 (0.56) | DRD4DRD2DRD3ALDH1A1HTR1A | |
| SCHEMBL8630582 | 0.84 | MAPT (0.54) | DRD4DRD2MEN1NPC1RAB9A | |
| SCHEMBL8633899 | 0.82 | KMT2A (0.50) | MEN1NPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL8628212 | 0.80 | SMO (0.42) | DRD4DRD2DRD3SLC6A2SLC6A4 | |
| SCHEMBL8627881 | 0.80 | MAPT (0.50) | DRD4DRD2DRD3SLC6A2SLC6A4 | |
| SCHEMBL8631540 | 0.79 | KCNH2 (0.51) | DRD4DRD2DRD3RAB9AALDH1A1 | |
| SCHEMBL8627836 | 0.78 | DRD4 (0.45) | DRD4DRD2DRD3MEN1NPC1 | |
| SCHEMBL29520874 | 0.78 | RECQL (0.53) | NPC1RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5780475-A | Antipsychotic indazole derivatives | MERCK, SHARP & DOHME LIMITED (GB) | 1998-07-14 | — | — | US | disclosed |