Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | DRD3 | P35462 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | DHFR | P00374 | 2/20 | 0.44 |
| ▸ | C1S | P09871 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17192216 | 0.87 | KCNH2 (0.61) | KCNH2HTR7HRH1HTR1AHTR2A | |
| SCHEMBL8631570 | 0.86 | MAPT (0.47) | HTR7HTR1ADRD3DRD2ALDH1A1 | |
| SCHEMBL8633681 | 0.86 | RECQL (0.50) | KCNH2HTR1ADRD3DRD2DRD4 | |
| SCHEMBL8630535 | 0.82 | SIGMAR1 (0.53) | KCNH2HTR7HTR1AHTR2ADRD3 | |
| SCHEMBL8629425 | 0.79 | DRD4 (0.56) | HTR1AHTR2CDRD3DRD2ALDH1A1 | |
| SCHEMBL8629124 | 0.79 | DRD4 (0.48) | HTR1ADRD3DRD2ALDH1A1RAB9A | |
| SCHEMBL8628296 | 0.79 | HTR7 (0.45) | HTR7HTR1ADRD3DRD2ADRB1 | |
| SCHEMBL8628029 | 0.78 | DRD2 (0.46) | KCNH2HTR7HTR1AHTR2AHTR2C | |
| SCHEMBL8630582 | 0.78 | MAPT (0.54) | HTR7HTR1ADRD2ALDH1A1MAPT | |
| SCHEMBL8631501 | 0.78 | SLC6A4 (0.44) | KCNH2HTR1ADRD3DRD2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5780475-A | Antipsychotic indazole derivatives | MERCK, SHARP & DOHME LIMITED (GB) | 1998-07-14 | — | — | US | disclosed |