Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | KMO | O15229 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8631570 | 0.84 | MAPT (0.47) | KMT2ANPC1POLBHSD17B10RECQL | |
| SCHEMBL8633681 | 0.84 | RECQL (0.50) | POLBHSD17B10RECQLL3MBTL1ADRA1D | |
| SCHEMBL8629425 | 0.82 | DRD4 (0.56) | POLBRECQLALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL8629124 | 0.82 | DRD4 (0.48) | KMT2ANPC1RAB9AL3MBTL1ALDH1A1 | |
| SCHEMBL8630582 | 0.81 | MAPT (0.54) | KMT2ANPC1RAB9APOLBHSD17B10 | |
| SCHEMBL8631540 | 0.76 | KCNH2 (0.51) | RAB9APOLBHSD17B10RECQLL3MBTL1 | |
| SCHEMBL8628296 | 0.74 | HTR7 (0.45) | POLBHSD17B10RECQLL3MBTL1ALDH1A1 | |
| SCHEMBL8627836 | 0.74 | DRD4 (0.45) | KMT2ANPC1RAB9APOLBHSD17B10 | |
| SCHEMBL29520874 | 0.74 | RECQL (0.53) | NPC1RAB9APOLBHSD17B10RECQL | |
| SCHEMBL8631501 | 0.74 | SLC6A4 (0.44) | KMT2APOLBHSD17B10RECQLALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5780475-A | Antipsychotic indazole derivatives | MERCK, SHARP & DOHME LIMITED (GB) | 1998-07-14 | — | — | US | disclosed |