Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1619616 | 0.89 | MAPT (0.40) | MAPTDPP4KDRKDM4ESMN1; SMN2 | |
| SCHEMBL862853 | 0.87 | MAPKAPK2 (0.39) | MAPTDPP4KDRKDM4ESMN1; SMN2 | |
| SCHEMBL14300726 | 0.86 | EPHX1 (0.37) | MAPTKDM4ESMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL863038 | 0.86 | ALDH1A1 (0.39) | DPP4KDRKDM4ESMN1; SMN2TSHR | |
| SCHEMBL1619623 | 0.86 | ALDH1A1 (0.39) | DPP4KDRKDM4ESMN1; SMN2TSHR | |
| SCHEMBL10037045 | 0.85 | DPP4 (0.38) | DPP4KDRKDM4ESMN1; SMN2TSHR | |
| SCHEMBL7841063 | 0.79 | MAPT (0.42) | MAPTKDM4ESMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL18952507 | 0.77 | MAPT (0.43) | MAPTDPP4KDRKDM4ESMN1; SMN2 | |
| SCHEMBL6877174 | 0.77 | ALDH1A1 (0.49) | MAPTKDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL16400707 | 0.76 | KDM4E (0.44) | MAPTDPP4KDRKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9115135-B2 | Process for the preparation of 2-amino-5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidine from 4-amino-2,5-dimethoxypyrimidine | DOW AGROSCIENCES LLC (US) | 2015-08-25 | — | — | US | disclosed |
| US-9115135-B2 | Process for the preparation of 2-amino-5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidine from 4-amino-2,5-dimethoxypyrimidine | DOW AGROSCIENCES LLC (US) | 2015-08-25 | — | — | US | disclosed |
| EP-2851367-A1 | Process for the preparation of a 2-amino-5,8-alkoxy[1,2,4]triazolo[1,5-c]pyrimidine by reaction of a 5-halo-8-alkoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-amine with an alkali metal alkoxide in an alcoholic solvent | Dow AgroSciences LLC (US) | 2015-03-25 | — | — | EP | disclosed |
| US-20140081024-A1 | PROCESS FOR THE PREPARATION OF 2-AMINO-5,8-DIMETHOXY[1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE FROM 4-AMINO-2,5-DIMETHOXYPYRIMIDINE | DOW AGROSCIENCES LLC (US) | 2014-03-20 | — | — | US | disclosed |
| WO-2014043148-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF 2-AMINO-5,8-DIMETHOXY[1,2,4]TRIAZOLO[1,5-C]PYRIMIDINE FROM 4-AMINO-2,5-DIMETHOXYPYRIMIDINE | DOW AGROSCIENCES LLC (US) | 2014-03-20 | — | — | WO | disclosed |
| US-20140081024-A1 | PROCESS FOR THE PREPARATION OF 2-AMINO-5,8-DIMETHOXY[1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE FROM 4-AMINO-2,5-DIMETHOXYPYRIMIDINE | DOW AGROSCIENCES LLC (US) | 2014-03-20 | — | — | US | disclosed |
| US-8338596-B2 | Process for the preparation of 5-substituted-8-alkoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-amines | DOW AGROSCIENCES LLC (US) | 2012-12-25 | — | — | US | disclosed |
| US-8338596-B2 | Process for the preparation of 5-substituted-8-alkoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-amines | DOW AGROSCIENCES LLC (US) | 2012-12-25 | — | — | US | disclosed |
| US-20120088913-A1 | PROCESS FOR THE PREPARATION OF 5-SUBSTITUTED-8-ALKOXY[1,2,4]TRIAZOLO[1,5-c]PYRIMIDIN-2-AMINES | DOW AGROSCIENCES LLC (US) | 2012-04-12 | — | — | US | disclosed |
| US-20120088913-A1 | PROCESS FOR THE PREPARATION OF 5-SUBSTITUTED-8-ALKOXY[1,2,4]TRIAZOLO[1,5-c]PYRIMIDIN-2-AMINES | DOW AGROSCIENCES LLC (US) | 2012-04-12 | — | — | US | disclosed |
| US-8143395-B2 | Process for the preparation of 5-substituted-8-alkoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-amines | DOW AGROSCIENCES LLC (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143395-B2 | Process for the preparation of 5-substituted-8-alkoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-amines | DOW AGROSCIENCES LLC (US) | 2012-03-27 | — | — | US | disclosed |
| US-20110295003-A1 | PROCESS FOR THE PREPARATION OF 5-SUBSTITUTED-8-ALKOXY[1,2,4]TRIAZOLO[1,5-c]PYRIMIDIN-2-AMINES | DOW AGROSCIENCES LLC (US) | 2011-12-01 | — | — | US | disclosed |
| US-20110295003-A1 | PROCESS FOR THE PREPARATION OF 5-SUBSTITUTED-8-ALKOXY[1,2,4]TRIAZOLO[1,5-c]PYRIMIDIN-2-AMINES | DOW AGROSCIENCES LLC (US) | 2011-12-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110295003-A1 | PROCESS FOR THE PREPARATION OF 5-SUBSTITUTED-8-ALKOXY[1,2,4]TRIAZOLO[1,5-c]PYRIMIDIN-2-AMINES | PAH, AZI2, ABL2 | MAPT 2607/4885DPP4 663/4885KDR 993/4885 |
| US-20120088913-A1 | PROCESS FOR THE PREPARATION OF 5-SUBSTITUTED-8-ALKOXY[1,2,4]TRIAZOLO[1,5-c]PYRIMIDIN-2-AMINES | PAH, AZI2, ABL2 | MAPT 2607/4885DPP4 663/4885KDR 993/4885 |
| US-20140081024-A1 | PROCESS FOR THE PREPARATION OF 2-AMINO-5,8-DIMETHOXY[1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE FROM 4-AMINO-2,5-DIMETHOXYPYRIMIDINE | DPYD, NUDT1, ALKBH5 | MAPT 3606/4885DPP4 1014/4885KDR 553/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.