Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 2/20 | 0.43 |
| ▸ | EDNRB | P24530 | 1/20 | 0.42 |
| ▸ | EDNRA | P25101 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.38 |
| ▸ | CDC25A | P30304 | 1/20 | 0.38 |
| ▸ | CDC25B | P30305 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8629982 | 0.93 | EDNRB (0.43) | CDC7EDNRBEDNRAPTGS2PTGDR2 | |
| SCHEMBL8635531 | 0.93 | PTGS2 (0.50) | CDC7EDNRBEDNRAPTGS2PTGDR2 | |
| SCHEMBL8629928 | 0.92 | PTGS2 (0.43) | CDC7PTGS2PTGDR2SMN1; SMN2KDM4E | |
| SCHEMBL8629382 | 0.90 | ALDH1A1 (0.41) | CDC7EDNRBEDNRAPTGS2PTGDR2 | |
| SCHEMBL8631438 | 0.90 | CYP1A2 (0.46) | PTGS2PPARGPTGDR2SMN1; SMN2KMT2A | |
| SCHEMBL8632875 | 0.87 | SMN1; SMN2 (0.50) | EDNRBEDNRAPTGS2PPARGSMN1; SMN2 | |
| SCHEMBL8630525 | 0.86 | CCR4 (0.41) | CDC7PTGS2PTGDR2SERPINE1SMN1; SMN2 | |
| SCHEMBL8632871 | 0.86 | MAPT (0.42) | CDC7PTGS2PPARGPTGDR2CDC25A | |
| SCHEMBL8631859 | 0.85 | KDM1A (0.41) | CDC7EDNRBEDNRAPTGDR2SMN1; SMN2 | |
| SCHEMBL8628839 | 0.84 | EDNRB (0.41) | EDNRBEDNRAPTGS2PPARGKEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |