Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 6/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.36 |
| ▸ | MARS1 | P56192 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.33 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8630356 | 0.89 | MARS1 (0.40) | PTGS2PTGS1HSD11B1F10PTGES2 | |
| SCHEMBL8627914 | 0.88 | PTGS2 (0.38) | PTGS2PTGS1HSD11B1F10PTGES2 | |
| SCHEMBL8631997 | 0.88 | PTGS2 (0.39) | PTGS2PTGS1HSD11B1F10CA2 | |
| SCHEMBL8630541 | 0.87 | PTGS2 (0.57) | PTGS2PTGS1F10F2PRSS1 | |
| SCHEMBL8631265 | 0.87 | PTGS2 (0.42) | PTGS2PTGS1HSD11B1F10CA2 | |
| SCHEMBL8631241 | 0.87 | F10 (0.38) | PTGS2PTGS1HSD11B1F10PTGES2 | |
| SCHEMBL8630202 | 0.83 | PTGS2 (0.49) | PTGS2PTGS1F10CA12CA2 | |
| SCHEMBL7777892 | 0.83 | PTGS2 (0.66) | PTGS2PTGS1CA12CA2CA9 | |
| SCHEMBL8628103 | 0.83 | PTGS2 (0.39) | PTGS2PTGS1HSD11B1F10CA12 | |
| SCHEMBL8634407 | 0.83 | PTGS2 (0.39) | PTGS2PTGS1HSD11B1F10CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |