Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.39 |
| ▸ | F10 | P00742 | 11/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.36 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.33 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8629763 | 0.87 | F10 (0.39) | PTGS2PTGS1F10F2PRSS1 | |
| SCHEMBL8631265 | 0.85 | PTGS2 (0.42) | PTGS2PTGS1F10HSD11B1PTGES2 | |
| SCHEMBL8631100 | 0.84 | PTGS2 (0.39) | PTGS2PTGS1F10F2CA12 | |
| SCHEMBL7780145 | 0.84 | PTGS1 (0.51) | PTGS2PTGS1CA12CA2CA9 | |
| SCHEMBL8627803 | 0.83 | PTGS2 (0.37) | PTGS2PTGS1F10F2PRSS1 | |
| SCHEMBL8630571 | 0.83 | PTGS2 (0.45) | PTGS2PTGS1F10HSD11B1PTGES2 | |
| SCHEMBL8628103 | 0.81 | PTGS2 (0.39) | PTGS2PTGS1F10HSD11B1PTGES2 | |
| SCHEMBL8631554 | 0.81 | PTGS2 (0.46) | PTGS2PTGS1F10F2TRPV1 | |
| SCHEMBL8631340 | 0.81 | PTGS2 (0.37) | PTGS2PTGS1F10F2CA12 | |
| SCHEMBL8630356 | 0.80 | MARS1 (0.40) | PTGS2PTGS1F10HSD11B1PTGES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |