Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.39 |
| ▸ | F10 | P00742 | 4/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.32 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.31 |
| ▸ | FEN1 | P39748 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8630571 | 0.88 | PTGS2 (0.45) | PTGS2PTGS1F10PTGES2HSD11B1 | |
| SCHEMBL8631579 | 0.88 | PTGS2 (0.42) | PTGS2PTGS1F10MAPT | |
| SCHEMBL8630356 | 0.87 | MARS1 (0.40) | PTGS2PTGS1F10PTGES2HSD11B1 | |
| SCHEMBL8631241 | 0.84 | F10 (0.38) | PTGS2PTGS1F10PTGES2HSD11B1 | |
| SCHEMBL7779843 | 0.84 | PTGS2 (0.50) | PTGS2PTGS1CA2CA9 | |
| SCHEMBL8627914 | 0.84 | PTGS2 (0.38) | PTGS2PTGS1F10PTGES2HSD11B1 | |
| SCHEMBL8629412 | 0.84 | PTGS2 (0.38) | PTGS2PTGS1F10CA1CA2 | |
| SCHEMBL8628841 | 0.83 | PTGS2 (0.43) | PTGS2PTGS1F10ALOX5APFEN1 | |
| SCHEMBL8631265 | 0.82 | PTGS2 (0.42) | PTGS2PTGS1F10PTGES2HSD11B1 | |
| SCHEMBL8630861 | 0.81 | PTGS2 (0.53) | PTGS2PTGS1F10ALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |