SCHEMBL8632099

SCHEMBL8632099

FC(F)(F)c1cc(Oc2ccc(-c3ccccc3)cc2)ccc1OCC=C(Br)Br

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AR P10275 3/20 0.38
RXRA P19793 1/20 0.38
RXRB P28702 1/20 0.38
RXRG P48443 1/20 0.38
NR1H2 P55055 4/20 0.37
NR1H3 Q13133 4/20 0.37
S1PR1 P21453 3/20 0.37
FFAR4 Q5NUL3 2/20 0.37
FFAR1 O14842 1/20 0.37
PPARD Q03181 1/20 0.36
PTGDR2 Q9Y5Y4 1/20 0.35
HTR2A P28223 1/20 0.34
SLC6A4 P31645 1/20 0.34
PTGER4 P35408 1/20 0.34
THRA P10827 1/20 0.34
THRB P10828 1/20 0.34
HDAC1 Q13547 1/20 0.34
HDAC2 Q92769 1/20 0.34
CTSS P25774 1/20 0.34
CTSK P43235 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8635708 0.94 AR (0.39) ARNR1H2NR1H3PPARDTHRA
SCHEMBL8633555 0.93 FFAR4 (0.40) ARRXRARXRBRXRGNR1H2
SCHEMBL8635881 0.92 NR1H2 (0.38) ARNR1H2NR1H3THRATHRB
SCHEMBL8636008 0.88 AR (0.38) ARRXRARXRBRXRGNR1H2
SCHEMBL8638227 0.87 PARG (0.39) ARTHRATHRB
SCHEMBL8638939 0.86 SLC6A4 (0.41) ARRXRARXRBRXRGPPARD
SCHEMBL8634753 0.85 AR (0.36) ARNR1H2NR1H3PPARDCTSS
SCHEMBL8632656 0.85 KDM4E (0.37) ARS1PR1
SCHEMBL8637887 0.85 L3MBTL1 (0.39) ARNR1H2NR1H3PTGDR2
SCHEMBL8638264 0.84 LMNA (0.44) ARRXRARXRBRXRGCTSS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0648729-B1 Dihalopropene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL CO (JP) 1998-07-15 EP disclosed
US-5698702-A INTERMEDIATES FOR INSECTICIDES, ACARICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1997-12-16 US disclosed
US-5530015-A Dihaloprene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient, and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-06-25 US disclosed
EP-0648729-A1 Dihalopropene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1995-04-19 EP disclosed