SCHEMBL8632656

SCHEMBL8632656

FC(F)(F)COc1ccc(Oc2ccc(OCC=C(Br)Br)c(C(F)(F)F)c2)cc1

nearest known ligand 0.37

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.37
ALDH1A1 P00352 4/20 0.37
RAB9A P51151 1/20 0.36
CYP2C9 P11712 2/20 0.35
CYP1A2 P05177 1/20 0.35
MEN1 O00255 1/20 0.34
LMNA P02545 1/20 0.34
KMT2A Q03164 1/20 0.34
PAX8 Q06710 1/20 0.34
POLB P06746 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
SCN8A Q9UQD0 1/20 0.34
SCN10A Q9Y5Y9 1/20 0.34
AR P10275 3/20 0.33
S1PR1 P21453 2/20 0.33
MAPK1 P28482 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
CYP17A1 P05093 1/20 0.33
CYP2C19 P33261 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8638264 0.89 LMNA (0.44) KDM4EMEN1LMNAKMT2APAX8
SCHEMBL8635708 0.89 AR (0.39) AR
SCHEMBL8638939 0.89 SLC6A4 (0.41) RAB9ALMNAAR
SCHEMBL8636074 0.88 KDM4E (0.37) KDM4EALDH1A1RAB9ACYP2C9CYP1A2
SCHEMBL8637887 0.88 L3MBTL1 (0.39) KDM4EALDH1A1RAB9AMEN1LMNA
SCHEMBL8632793 0.87 LTA4H (0.43) LMNAARS1PR1
SCHEMBL8632120 0.87 LTA4H (0.43) MEN1LMNAKMT2ASCN8ASCN10A
SCHEMBL8635881 0.86 NR1H2 (0.38) KDM4EALDH1A1MEN1KMT2AAR
SCHEMBL8633959 0.85 MAPT (0.39) KDM4EALDH1A1RAB9ALMNAPOLB
SCHEMBL8632099 0.85 AR (0.38) ARS1PR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0648729-B1 Dihalopropene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL CO (JP) 1998-07-15 EP disclosed
US-5698702-A INTERMEDIATES FOR INSECTICIDES, ACARICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1997-12-16 US disclosed
US-5530015-A Dihaloprene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient, and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-06-25 US disclosed
EP-0648729-A1 Dihalopropene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1995-04-19 EP disclosed