SCHEMBL8638264

SCHEMBL8638264

CCOc1ccc(Oc2ccc(OCC=C(Br)Br)c(C(F)(F)F)c2)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.44
MAPT P10636 2/20 0.44
ATM Q13315 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
AR P10275 3/20 0.41
LTA4H P09960 2/20 0.40
RXRA P19793 1/20 0.39
RXRB P28702 1/20 0.39
RXRG P48443 1/20 0.39
MAPK8 P45983 1/20 0.37
MAPK10 P53779 1/20 0.37
PDE3B Q13370 1/20 0.36
PDE3A Q14432 1/20 0.36
KMT2A Q03164 2/20 0.36
MEN1 O00255 1/20 0.36
PAX8 Q06710 1/20 0.36
KDM4E B2RXH2 1/20 0.36
CTSS P25774 1/20 0.36
SCN8A Q9UQD0 1/20 0.35
SCN10A Q9Y5Y9 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8636967 0.92 MAPK1 (0.43) LMNAMAPTATML3MBTL1AR
SCHEMBL8632793 0.91 LTA4H (0.43) LMNAMAPTATML3MBTL1AR
SCHEMBL8632120 0.91 LTA4H (0.43) LMNAMAPTATML3MBTL1AR
SCHEMBL8632656 0.89 KDM4E (0.37) LMNAARKMT2AMEN1PAX8
SCHEMBL8637887 0.89 L3MBTL1 (0.39) LMNAMAPTATML3MBTL1AR
SCHEMBL8631816 0.89 LTA4H (0.41) LMNAMAPTATML3MBTL1AR
SCHEMBL8635048 0.88 MAPT (0.44) LMNAMAPTATML3MBTL1AR
SCHEMBL8638939 0.88 SLC6A4 (0.41) LMNAMAPTATML3MBTL1AR
SCHEMBL8635708 0.88 AR (0.39) ARRAF1MAOB
SCHEMBL8636796 0.88 AR (0.42) LMNAMAPTATML3MBTL1AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0648729-B1 Dihalopropene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL CO (JP) 1998-07-15 EP disclosed
US-5698702-A INTERMEDIATES FOR INSECTICIDES, ACARICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1997-12-16 US disclosed
US-5530015-A Dihaloprene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient, and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-06-25 US disclosed
EP-0648729-A1 Dihalopropene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1995-04-19 EP disclosed