Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.43 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.42 |
| ▸ | CCNC | P24863 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.42 |
| ▸ | F10 | P00742 | 5/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8637462 | 0.78 | HRH3 (0.42) | HRH3CCNCCDK8F10 | |
| SCHEMBL8637204 | 0.75 | HRH3 (0.44) | HRH3CCNCCDK8ITGB3ITGA2B | |
| SCHEMBL8632718 | 0.72 | CYP2C9 (0.45) | HRH3SPHK1CCNCCDK8ITGB3 | |
| SCHEMBL6160214 | 0.71 | SPHK1 (0.46) | HRH3SPHK1ITGB3ITGA2B | |
| SCHEMBL21385141 | 0.70 | MAPT (0.45) | — | |
| SCHEMBL8683270 | 0.69 | F10 (0.44) | HRH3CCNCCDK8ITGB3ITGA2B | |
| SCHEMBL8632723 | 0.68 | CHRM3 (0.49) | HRH3ITGB3ITGA2BHRH1 | |
| SCHEMBL7334680 | 0.68 | CHKA (0.52) | HRH3ITGB3ITGA2B | |
| SCHEMBL7334443 | 0.67 | SMN1; SMN2 (0.56) | — | |
| SCHEMBL8632780 | 0.67 | F10 (0.45) | HRH3F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753659-A | ANTICOAGULANTS FOR BLOOD DISORDER, CARDIOVASCULAR DISORDER, THROMBOSIS, | ZENECA LIMITED (GB) | 1998-05-19 | — | — | US | disclosed |
| US-5750754-A | TERTIARY BUTYL 3-METHYL-4-SUBSTITUTED BUTYRATE; CHEMICAL INTERMEDIATES FOR ANTICAOGULANT DRUGS | ZENECA LIMITED (GB) | 1998-05-12 | — | — | US | disclosed |
| US-5728701-A | INHIBIT PLATELET AGGREGATION | ZENECA LIMITED (GB) | 1998-03-17 | — | — | US | disclosed |