SCHEMBL8632777

SCHEMBL8632777

FC(F)(F)c1cc(Oc2cccc(-c3ccccc3)c2)ccc1OCC=C(Cl)Cl

nearest known ligand 0.40

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
FFAR4 Q5NUL3 3/20 0.40
FFAR1 O14842 2/20 0.40
NR1H2 P55055 8/20 0.40
NR1H3 Q13133 8/20 0.40
HDAC1 Q13547 1/20 0.37
HDAC2 Q92769 1/20 0.37
AR P10275 3/20 0.37
RXRA P19793 1/20 0.37
RXRB P28702 1/20 0.37
RXRG P48443 1/20 0.37
CETP P11597 1/20 0.35
SCN9A Q15858 1/20 0.35
MRGPRX4 Q96LA9 1/20 0.35
THRA P10827 1/20 0.35
THRB P10828 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8636008 0.93 AR (0.38) FFAR4FFAR1NR1H2NR1H3AR
SCHEMBL8638861 0.92 AR (0.38) NR1H2NR1H3ARMRGPRX4
SCHEMBL8634174 0.92 AR (0.39) FFAR4NR1H2NR1H3HDAC1HDAC2
SCHEMBL8633555 0.89 FFAR4 (0.40) FFAR4FFAR1NR1H2NR1H3HDAC1
SCHEMBL8635779 0.88 AR (0.39) NR1H2NR1H3ARMRGPRX4
SCHEMBL8633081 0.86 MAOB (0.43) ARRXRARXRBRXRGMRGPRX4
SCHEMBL8633895 0.86 AR (0.51) FFAR1ARMRGPRX4
SCHEMBL8633011 0.85 MAPT (0.43) AR
SCHEMBL8631990 0.85 PARG (0.41) ARMRGPRX4
SCHEMBL8636591 0.84 MAPK1 (0.43) ARRXRARXRBRXRGCETP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0648729-B1 Dihalopropene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL CO (JP) 1998-07-15 EP disclosed
US-5698702-A INTERMEDIATES FOR INSECTICIDES, ACARICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1997-12-16 US disclosed
US-5530015-A Dihaloprene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient, and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-06-25 US disclosed
EP-0648729-A1 Dihalopropene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1995-04-19 EP disclosed