SCHEMBL8638567

SCHEMBL8638567

O=CCOc1ccc(Oc2cccc(Cl)c2)cc1Br

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 3/20 0.38
LMNA P02545 3/20 0.38
PPARG P37231 2/20 0.38
PPARD Q03181 2/20 0.38
FFAR1 O14842 2/20 0.38
SLC6A2 P23975 1/20 0.37
SLC6A3 Q01959 1/20 0.37
HTR2A P28223 1/20 0.37
KCNH2 Q12809 1/20 0.37
ADRB1 P08588 1/20 0.37
ADRB3 P13945 1/20 0.37
CYP1A2 P05177 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
EGFR P00533 1/20 0.36
LCK P06239 1/20 0.36
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
NPSR1 Q6W5P4 1/20 0.36
KDM4E B2RXH2 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8635839 0.84 PPARG (0.39) SLC6A4LMNAPPARGPPARDFFAR1
SCHEMBL8633461 0.84 PPARG (0.39) SLC6A4LMNAPPARGPPARDFFAR1
SCHEMBL3736848 0.77 WDR5 (0.50) LMNAKCNH2MEN1KMT2AKDM4E
SCHEMBL29705544 0.77 WDR5 (0.50) LMNAKCNH2MEN1KMT2AKDM4E
SCHEMBL8633981 0.73 EPAS1 (0.38) LMNAMAPT
SCHEMBL8636441 0.73 EPAS1 (0.38) LMNAKDM4EMAPT
SCHEMBL8632883 0.72 PPARD (0.39) SLC6A4LMNAPPARGPPARDFFAR1
SCHEMBL8634621 0.72 MAOB (0.37) LMNACYP1A2CYP2C9CYP2C19EGFR
SCHEMBL25998819 0.71 ALDH1A1 (0.45) SLC6A4FFAR1SLC6A3
SCHEMBL9321546 0.71 DRD2 (0.49) SLC6A4LMNAPPARGPPARDFFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0648729-B1 Dihalopropene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL CO (JP) 1998-07-15 EP disclosed
US-5698702-A INTERMEDIATES FOR INSECTICIDES, ACARICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1997-12-16 US disclosed
US-5530015-A Dihaloprene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient, and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-06-25 US disclosed
EP-0648729-A1 Dihalopropene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1995-04-19 EP disclosed