Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 12/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.34 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8633221 | 0.90 | PTGS2 (0.38) | F10CA1CA2CA9PTGS2 | |
| SCHEMBL8630040 | 0.88 | POLB (0.36) | F10LRRK2POLBCA2CA9 | |
| SCHEMBL8633695 | 0.88 | F10 (0.39) | F10LRRK2CA1CA2CA9 | |
| SCHEMBL8629079 | 0.86 | F10 (0.36) | F10LRRK2POLBCA1CA2 | |
| SCHEMBL8635633 | 0.85 | AR (0.36) | F10PTGS2F2PRSS1PRSS2 | |
| SCHEMBL8634661 | 0.85 | PTGS2 (0.45) | F10POLBPTGS2F2PRSS1 | |
| SCHEMBL7780018 | 0.83 | CA9 (0.47) | CA1CA2CA9PTGS2CA4 | |
| SCHEMBL8633616 | 0.83 | PTGS2 (0.39) | F10CA1CA2CA9PTGS2 | |
| SCHEMBL8632205 | 0.83 | PTGS2 (0.45) | F10POLBCA1CA2CA9 | |
| SCHEMBL8633822 | 0.83 | POLB (0.33) | F10LRRK2POLBCA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |