Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | BUB1 | O43683 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8636934 | 0.90 | MAPT (0.36) | GAAL3MBTL1MAPTNPSR1ADAM17 | |
| SCHEMBL8632567 | 0.79 | GFER (0.39) | MAPTNPSR1ROCK2PRKG1GFER | |
| SCHEMBL8637925 | 0.79 | GFER (0.38) | GAANPC1RAB9AGFERTSHR | |
| Hydrochloric Acid SCHEMBL8637210 | 0.79 | GFER (0.38) | MAPTNPSR1ROCK2PRKG1GFER | |
| SCHEMBL8632725 | 0.76 | ALDH1A1 (0.36) | GAAL3MBTL1NPSR1 | |
| SCHEMBL8697195 | 0.74 | ROCK2 (0.38) | GAANPSR1ROCK2TSHR | |
| SCHEMBL27442362 | 0.73 | GAA (0.43) | GAAMAPTNPSR1ROCK2TSHR | |
| SCHEMBL8633503 | 0.72 | MAPT (0.34) | MAPTNPSR1MEN1GFERKMT2A | |
| SCHEMBL8633129 | 0.69 | KDM4D (0.35) | GAAL3MBTL1NPSR1ROCK2KMT2A | |
| SCHEMBL8686282 | 0.68 | ROCK2 (0.35) | ROCK2PRKG1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753659-A | ANTICOAGULANTS FOR BLOOD DISORDER, CARDIOVASCULAR DISORDER, THROMBOSIS, | ZENECA LIMITED (GB) | 1998-05-19 | — | — | US | disclosed |
| US-5750754-A | TERTIARY BUTYL 3-METHYL-4-SUBSTITUTED BUTYRATE; CHEMICAL INTERMEDIATES FOR ANTICAOGULANT DRUGS | ZENECA LIMITED (GB) | 1998-05-12 | — | — | US | disclosed |
| US-5728701-A | INHIBIT PLATELET AGGREGATION | ZENECA LIMITED (GB) | 1998-03-17 | — | — | US | disclosed |