Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8635203 | 0.90 | HSP90AA1 (0.35) | LMNAALDH1A1TP53SMN1; SMN2BCAT2 | |
| SCHEMBL8634362 | 0.85 | NSD2 (0.40) | BCAT2NSD2ESR1POLBAPEX1 | |
| SCHEMBL8634309 | 0.82 | SLC9A1 (0.31) | — | |
| SCHEMBL7766603 | 0.82 | SLC9A1 (0.49) | — | |
| SCHEMBL8634234 | 0.81 | MEN1 (0.36) | SMN1; SMN2ESR1POLBMEN1KMT2A | |
| SCHEMBL8633117 | 0.81 | PDE4B (0.40) | LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL8635259 | 0.80 | ALDH1A1 (0.38) | ALDH1A1ESR1KMT2A | |
| SCHEMBL8635349 | 0.80 | ALDH1A1 (0.39) | LMNAALDH1A1SMN1; SMN2POLBTDP1 | |
| SCHEMBL8633074 | 0.79 | CYP3A4 (0.37) | LMNAALDH1A1TP53TSHR | |
| SCHEMBL8634504 | 0.79 | FLT1 (0.38) | LMNAALDH1A1MEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739142-A | 4-aminobenzoylguanidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-04-14 | — | — | US | disclosed |