Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.32 |
| ▸ | PER2 | O15055 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8635496 | 0.87 | ALDH1A1 (0.39) | ALDH1A1ALOX15KMT2AKAT6A | |
| SCHEMBL8634234 | 0.87 | MEN1 (0.36) | KMT2AESR1GAA | |
| SCHEMBL8635203 | 0.85 | HSP90AA1 (0.35) | ALDH1A1KMT2AESR1THRB | |
| SCHEMBL8633152 | 0.85 | RORC (0.38) | ESR1 | |
| SCHEMBL7764092 | 0.85 | SLC9A1 (0.44) | — | |
| SCHEMBL8634165 | 0.84 | ESR1 (0.39) | ALDH1A1KMT2AESR1 | |
| SCHEMBL8636231 | 0.83 | MCL1 (0.33) | ALDH1A1ALOX15KMT2ARIPK1 | |
| SCHEMBL8636273 | 0.83 | ALDH1A1 (0.36) | ALDH1A1 | |
| SCHEMBL8635349 | 0.83 | ALDH1A1 (0.39) | ALDH1A1KMT2ARIPK1PER2 | |
| SCHEMBL8631189 | 0.81 | MEN1 (0.31) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1057999-C | 4-Aminobenzoylguanidine derivatives | MERCK PATENT GMBH (DE) | 2000-11-01 | — | — | CN | disclosed |
| US-5739142-A | 4-aminobenzoylguanidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-04-14 | — | — | US | disclosed |
| CN-1138575-A | 4-aminobenzoylguanidine derivatives | MERCK PATENT GMBH (DE) | 1996-12-25 | — | — | CN | disclosed |