Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.33 |
| ▸ | THRA | P10827 | 2/20 | 0.33 |
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8635246 | 0.90 | LMNA (0.35) | MEN1KMT2AALDH1A1LMNATP53 | |
| SCHEMBL8634504 | 0.89 | FLT1 (0.38) | MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL8633117 | 0.88 | PDE4B (0.40) | MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL8636231 | 0.88 | MCL1 (0.33) | KMT2AALDH1A1LMNATP53L3MBTL1 | |
| SCHEMBL8635757 | 0.88 | SMN1; SMN2 (0.31) | ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL8635349 | 0.87 | ALDH1A1 (0.39) | MEN1KMT2AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL8634234 | 0.86 | MEN1 (0.36) | MEN1KMT2ASMN1; SMN2ESR1POLB | |
| SCHEMBL8633074 | 0.86 | CYP3A4 (0.37) | ALDH1A1LMNATP53 | |
| SCHEMBL8632126 | 0.86 | TUBB4A (0.37) | HSP90AA1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL8635259 | 0.85 | ALDH1A1 (0.38) | KMT2AALDH1A1THRBESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739142-A | 4-aminobenzoylguanidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-04-14 | — | — | US | disclosed |