Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | ACHE | P22303 | 4/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 3/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8639858 | 0.91 | ALDH1A1 (0.37) | ALDH1A1ACHEPTGS2MAPTBCHE | |
| SCHEMBL9167754 | 0.85 | ALDH1A1 (0.36) | ALDH1A1ACHEKDM4ESMN1; SMN2MAOB | |
| SCHEMBL9170026 | 0.83 | ROCK2 (0.40) | ALDH1A1ACHEKDM4ESMN1; SMN2MAOB | |
| SCHEMBL8641204 | 0.83 | ACHE (0.38) | ALDH1A1ACHEGAACHRNB4CHRNA3 | |
| SCHEMBL8638777 | 0.83 | MAOA (0.38) | MAOB | |
| SCHEMBL9166368 | 0.83 | ACHE (0.32) | ALDH1A1ACHEPTGS2MAOBROCK2 | |
| SCHEMBL8656492 | 0.80 | ROCK2 (0.37) | ACHEMAOBROCK2ROCK1 | |
| Sinitrodil SCHEMBL31066546 | 0.80 | TSHR (0.34) | ALDH1A1PTGS2KDM4EHPGDSMN1; SMN2 | |
| Sinitrodil SCHEMBL503115 | 0.80 | TSHR (0.34) | ALDH1A1PTGS2KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL8658972 | 0.80 | SMN1; SMN2 (0.39) | ALDH1A1PTGS2KDM4ESMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5480882-A | Benzoxazinone and benzothiazinone derivatives having cardiovascular activity | ITALFARMACO S.P.A. (IT) | 1996-01-02 | — | — | US | claimed |
| EP-0566018-B1 | Benzoxazinone and benzothiazinone derivatives endowed with cardiovascular activity | ITALFARMACO SPA (IT) | 1998-08-05 | — | — | EP | disclosed |
| US-5480882-A | Benzoxazinone and benzothiazinone derivatives having cardiovascular activity | ITALFARMACO S.P.A. (IT) | 1996-01-02 | — | — | US | disclosed |
| EP-0566018-A2 | Benzoxazinone and benzothiazinone derivatives endowed with cardiovascular activity | ITALFARMACO S.p.A. (IT) | 1993-10-20 | — | — | EP | disclosed |