Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 10/20 | 0.47 |
| ▸ | JAK1 | P23458 | 8/20 | 0.47 |
| ▸ | JAK2 | O60674 | 6/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8634805 | 0.86 | TYK2 (0.48) | TYK2JAK1JAK2KCNH2KIT | |
| SCHEMBL8634357 | 0.86 | TYK2 (0.34) | TYK2JAK1JAK2KCNH2KIT | |
| SCHEMBL7764917 | 0.84 | SLC9A1 (0.44) | — | |
| SCHEMBL8635140 | 0.82 | BCAT2 (0.42) | MEN1GFERKMT2A | |
| SCHEMBL8634502 | 0.80 | PTGS1 (0.38) | KMT2ATSHRMAPK1RAB9ASMN1; SMN2 | |
| SCHEMBL8634536 | 0.80 | CXCL8 (0.43) | TYK2JAK1JAK2MEN1KMT2A | |
| SCHEMBL8635172 | 0.79 | CXCL8 (0.42) | TYK2JAK1JAK2KCNH2KIT | |
| SCHEMBL8635462 | 0.79 | PDE4B (0.41) | NPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL8630815 | 0.78 | ACP1 (0.40) | KCNH2MEN1KMT2ANPC1RAB9A | |
| SCHEMBL8636186 | 0.77 | AKR1C3 (0.44) | MEN1KMT2ANPC1TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1057999-C | 4-Aminobenzoylguanidine derivatives | MERCK PATENT GMBH (DE) | 2000-11-01 | — | — | CN | disclosed |
| US-5739142-A | 4-aminobenzoylguanidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-04-14 | — | — | US | disclosed |
| CN-1138575-A | 4-aminobenzoylguanidine derivatives | MERCK PATENT GMBH (DE) | 1996-12-25 | — | — | CN | disclosed |