Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCL8 | P10145 | 1/20 | 0.42 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 5/20 | 0.36 |
| ▸ | JAK2 | O60674 | 4/20 | 0.36 |
| ▸ | JAK1 | P23458 | 4/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8634536 | 0.87 | CXCL8 (0.43) | CXCL8MAPTSMN1; SMN2ALDH1A1TYK2 | |
| SCHEMBL8631388 | 0.85 | GAA (0.40) | CXCL8MAPTSMN1; SMN2ALDH1A1ALOX15 | |
| SCHEMBL8633397 | 0.85 | AKR1C3 (0.43) | MAPTSMN1; SMN2ALDH1A1TSHRNPC1 | |
| SCHEMBL8635140 | 0.84 | BCAT2 (0.42) | MAPTALDH1A1ALOX15GAAMEN1 | |
| SCHEMBL8636186 | 0.84 | AKR1C3 (0.44) | MAPTSMN1; SMN2ALDH1A1TSHRNPC1 | |
| SCHEMBL7768639 | 0.83 | SLC9A1 (0.45) | — | |
| SCHEMBL8633057 | 0.83 | L3MBTL1 (0.41) | ALDH1A1ALOX15TSHRGAALMNA | |
| SCHEMBL8635300 | 0.82 | HTT (0.38) | MAPTALDH1A1HTT | |
| SCHEMBL8632359 | 0.81 | MEN1 (0.44) | MAPTSMN1; SMN2GAARAB9AHTT | |
| SCHEMBL8635911 | 0.79 | TYK2 (0.47) | SMN1; SMN2TSHRTYK2JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1057999-C | 4-Aminobenzoylguanidine derivatives | MERCK PATENT GMBH (DE) | 2000-11-01 | — | — | CN | disclosed |
| US-5739142-A | 4-aminobenzoylguanidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-04-14 | — | — | US | disclosed |
| CN-1138575-A | 4-aminobenzoylguanidine derivatives | MERCK PATENT GMBH (DE) | 1996-12-25 | — | — | CN | disclosed |