Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 2/20 | 0.38 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8635848 | 0.86 | CYP11B2 (0.46) | PDE4BALDH1A1ALPLNAMPTNPC1 | |
| SCHEMBL8634502 | 0.86 | PTGS1 (0.38) | ALDH1A1PTGS1RAB9ASMN1; SMN2 | |
| SCHEMBL8635140 | 0.86 | BCAT2 (0.42) | ALDH1A1POLB | |
| SCHEMBL7765590 | 0.84 | — | — | |
| SCHEMBL8633209 | 0.82 | MEN1 (0.43) | PDE4BALDH1A1PTGS1SMN1; SMN2 | |
| SCHEMBL8632359 | 0.81 | MEN1 (0.44) | PTGS1RAB9ASMN1; SMN2 | |
| SCHEMBL8634357 | 0.80 | TYK2 (0.34) | — | |
| SCHEMBL8633969 | 0.80 | CNR2 (0.43) | PTGS1POLB | |
| SCHEMBL8635300 | 0.79 | HTT (0.38) | ALDH1A1PTGS1 | |
| SCHEMBL8635178 | 0.79 | AKR1C3 (0.48) | PDE4BPTGS1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1057999-C | 4-Aminobenzoylguanidine derivatives | MERCK PATENT GMBH (DE) | 2000-11-01 | — | — | CN | disclosed |
| US-5739142-A | 4-aminobenzoylguanidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-04-14 | — | — | US | disclosed |
| CN-1138575-A | 4-aminobenzoylguanidine derivatives | MERCK PATENT GMBH (DE) | 1996-12-25 | — | — | CN | disclosed |