Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 3/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SCN4A | P35499 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TERT | O14746 | 1/20 | 0.38 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.38 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8684911 | 0.89 | CYP1A2 (0.45) | RAB9ACYP1A2CYP3A4CYP2D6CYP19A1 | |
| SCHEMBL8639331 | 0.88 | LTA4H (0.49) | LTA4HCYP1A2CYP3A4CYP2D6CYP19A1 | |
| SCHEMBL8684972 | 0.81 | FPR2 (0.43) | RAB9ACYP1A2CYP3A4CYP2D6CYP19A1 | |
| SCHEMBL8690250 | 0.81 | HRH3 (0.48) | RAB9ACYP1A2CYP3A4CYP2D6CYP19A1 | |
| SCHEMBL28261194 | 0.81 | TAAR1 (0.46) | RAB9ACYP1A2CYP3A4CYP2D6CYP19A1 | |
| SCHEMBL6181232 | 0.81 | NPC1 (0.49) | RAB9ACYP1A2CYP3A4CYP2D6CYP19A1 | |
| SCHEMBL11581355 | 0.80 | TAAR1 (0.53) | LTA4HCYP1A2CYP3A4CYP2D6CYP19A1 | |
| SCHEMBL3979810 | 0.80 | MAOB (0.43) | TRPA1RAB9ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8686276 | 0.80 | NOS1 (0.46) | LTA4HCYP1A2CYP3A4CYP2D6CYP19A1 | |
| SCHEMBL8637455 | 0.80 | LTA4H (0.51) | LTA4HCYP1A2CYP3A4CYP2D6CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |