SCHEMBL8637231

SCHEMBL8637231

Fc1cc(F)cc(-c2[c]c(-c3ccc(Cl)cc3Cl)ccn2)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 3/20 0.41
NPC1 O15118 4/20 0.40
RAB9A P51151 3/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
KDM4E B2RXH2 2/20 0.40
TP53 P04637 1/20 0.40
MAPT P10636 4/20 0.38
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
EGLN2 Q96KS0 1/20 0.38
GCGR P47871 1/20 0.37
MAPK14 Q16539 1/20 0.37
AHR P35869 1/20 0.37
CNR1 P21554 2/20 0.35
PIK3CA P42336 1/20 0.35
PIK3CB P42338 1/20 0.35
PIK3CG P48736 1/20 0.35
CNR2 P34972 1/20 0.35
AQP1 P29972 1/20 0.34
ALDH1A1 P00352 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31339480 0.74 AHR (0.63) DPP4NPC1RAB9ASMN1; SMN2KDM4E
SCHEMBL14880353 0.68 NOTUM (0.38) NPC1RAB9ASMN1; SMN2KDM4ETP53
SCHEMBL15637534 0.67 TGFBR1 (0.35) MAPK14L3MBTL1
SCHEMBL15637337 0.64 AHR (0.59) NPC1RAB9ASMN1; SMN2KDM4ETP53
SCHEMBL435140 0.64 AHR (0.40) DPP4NPC1RAB9ASMN1; SMN2KDM4E
SCHEMBL9009025 0.64 AHR (0.53) DPP4NPC1RAB9ASMN1; SMN2KDM4E
SCHEMBL28635233 0.64 EGLN2 (0.41) NPC1RAB9ASMN1; SMN2KDM4ETP53
SCHEMBL29097482 0.63 AHR (0.42) DPP4NPC1RAB9ASMN1; SMN2KDM4E
SCHEMBL27631421 0.63 SMN1; SMN2 (0.45) DPP4NPC1RAB9ASMN1; SMN2KDM4E
SCHEMBL1275106 0.63 MAPT (0.42) NPC1RAB9ASMN1; SMN2TP53MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0853764-A1 COMBINATORIAL SYNTHESIS AND HIGH-THROUGHPUT SCREENING OF A REV-INHIBITING ARYLIDENEDIAMIDE ARRAY ARQULE, INC. (US) 1998-07-22 EP claimed
WO-1996035953-A1 COMBINATORIAL SYNTHESIS AND HIGH-THROUGHPUT SCREENING OF A REV-INHIBITING ARYLIDENEDIAMIDE ARRAY ARQULE, INC. (US) 1996-11-14 WO claimed
EP-0853764-A1 COMBINATORIAL SYNTHESIS AND HIGH-THROUGHPUT SCREENING OF A REV-INHIBITING ARYLIDENEDIAMIDE ARRAY ARQULE, INC. (US) 1998-07-22 EP disclosed
WO-1996035953-A1 COMBINATORIAL SYNTHESIS AND HIGH-THROUGHPUT SCREENING OF A REV-INHIBITING ARYLIDENEDIAMIDE ARRAY ARQULE, INC. (US) 1996-11-14 WO disclosed