Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8635978 | 0.80 | LTA4H (0.43) | LTA4H | |
| SCHEMBL8644157 | 0.78 | LTA4H (0.39) | LTA4H | |
| SCHEMBL8644274 | 0.71 | LTA4H (0.41) | LTA4HCYP2C9HTT | |
| SCHEMBL5653626 | 0.71 | KMT2A (0.72) | KMT2ASMN1; SMN2MEN1KDM4ENPC1 | |
| SCHEMBL1516144 | 0.68 | MAPT (0.82) | FKBP1AMAPTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL11117435 | 0.68 | MAPT (0.67) | FKBP1AMAPTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL17338907 | 0.67 | HRH3 (0.64) | FKBP1AMAPTKMT2ASMN1; SMN2HTT | |
| Hydrochloric Acid SCHEMBL68316 | 0.67 | MAPT (0.79) | FKBP1AMAPTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL8644118 | 0.66 | LTA4H (0.39) | LTA4H | |
| SCHEMBL7132003 | 0.66 | LTA4H (0.65) | FKBP1ARAB9ALTA4HCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |