Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 12/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 3/20 | 0.37 |
| ▸ | PPARA | Q07869 | 3/20 | 0.37 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8635978 | 0.87 | LTA4H (0.43) | LTA4HCA12CA1CA2CA9 | |
| SCHEMBL8644274 | 0.78 | LTA4H (0.41) | LTA4HPPARGPPARAPLA2G10PLA2G2A | |
| SCHEMBL8637359 | 0.78 | FKBP1A (0.46) | LTA4H | |
| SCHEMBL8644118 | 0.72 | LTA4H (0.39) | LTA4HPPARGPPARAPLA2G10PLA2G2A | |
| SCHEMBL8639571 | 0.70 | LTA4H (0.44) | LTA4HLMNA | |
| SCHEMBL11066953 | 0.69 | OPRK1 (0.63) | LTA4HPPARGPPARALMNA | |
| SCHEMBL8639342 | 0.69 | ELANE (0.43) | LTA4HCA12CA1CA2CA9 | |
| SCHEMBL11335723 | 0.69 | LTA4H (0.46) | LTA4HPPARGPPARALMNASRD5A2 | |
| SCHEMBL8644119 | 0.68 | PPARG (0.47) | LTA4HPPARGPPARAPLA2G10PLA2G2A | |
| SCHEMBL8639361 | 0.68 | OPRK1 (0.39) | LTA4HPPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |