Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 10/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 5/20 | 0.38 |
| ▸ | PPARA | Q07869 | 5/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8640499 | 0.85 | LTA4H (0.41) | LTA4HELANEPPARGPPARAOPRK1 | |
| SCHEMBL8641132 | 0.84 | LTA4H (0.42) | LTA4H | |
| SCHEMBL11335723 | 0.80 | LTA4H (0.46) | LTA4HELANEPPARGPPARAOPRK1 | |
| SCHEMBL8907701 | 0.79 | PPARA (0.40) | LTA4HPPARGPPARA | |
| SCHEMBL8639361 | 0.76 | OPRK1 (0.39) | LTA4HELANEPPARGPPARAOPRK1 | |
| SCHEMBL8635978 | 0.74 | LTA4H (0.43) | LTA4HELANEPPARGPPARAPLA2G10 | |
| SCHEMBL14431994 | 0.74 | S1PR4 (0.43) | ELANEPPARGPPARALMNA | |
| SCHEMBL8641992 | 0.73 | S1PR1 (0.36) | LTA4HPPARGPPARA | |
| SCHEMBL8644157 | 0.72 | LTA4H (0.39) | LTA4HPPARGPPARAPLA2G10PLA2G2A | |
| SCHEMBL11066953 | 0.72 | OPRK1 (0.63) | LTA4HELANEPPARGPPARAOPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5700816-A | ANTIARTHRITIC AGENTS | G.D. SEARLE & CO. | 1997-12-23 | — | — | US | claimed |
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |