Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 6/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 6/20 | 0.35 |
| ▸ | PPARA | Q07869 | 5/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.33 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.33 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8635978 | 0.80 | LTA4H (0.43) | LTA4HS1PR1S1PR3ELANEPPARG | |
| SCHEMBL8644157 | 0.78 | LTA4H (0.39) | LTA4HPPARGPPARASRD5A2PLA2G10 | |
| SCHEMBL11335723 | 0.74 | LTA4H (0.46) | LTA4HCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL18333223 | 0.73 | LTA4H (0.52) | LTA4HCYP2D6ELANELMNA | |
| SCHEMBL1452863 | 0.72 | LTA4H (0.39) | LTA4HL3MBTL1PPARGPPARA | |
| SCHEMBL8637359 | 0.71 | FKBP1A (0.46) | LTA4HCYP2C9HTT | |
| SCHEMBL5280435 | 0.71 | LTA4H (0.36) | LTA4HL3MBTL1 | |
| SCHEMBL17772105 | 0.70 | PPARG (0.37) | LTA4HCYP2D6L3MBTL1PPARGPPARA | |
| SCHEMBL8644118 | 0.70 | LTA4H (0.39) | LTA4HELANEPPARGPPARAOPRK1 | |
| SCHEMBL4980283 | 0.70 | ELANE (0.39) | LTA4HCYP1A2CYP2D6CYP2C19S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |