SCHEMBL8637379

SCHEMBL8637379

FC(F)=C(F)Oc1ccc2ccc(OC(F)=C(F)F)cc2c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 10/20 0.42
MEN1 O00255 8/20 0.42
MAPT P10636 3/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
HTT P42858 1/20 0.42
TDP1 Q9NUW8 1/20 0.41
TSHR P16473 1/20 0.40
ESR1 P03372 4/20 0.39
ESR2 Q92731 2/20 0.39
L3MBTL1 Q9Y468 1/20 0.37
ALDH1A1 P00352 1/20 0.37
HSD17B10 Q99714 1/20 0.37
CYP1A2 P05177 1/20 0.37
CYP2A6 P11509 1/20 0.37
BCHE P06276 1/20 0.37
CASP3 P42574 2/20 0.36
SENP8 Q96LD8 2/20 0.36
SENP7 Q9BQF6 2/20 0.36
SENP6 Q9GZR1 2/20 0.36
NPC1 O15118 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8665021 0.95 KMT2A (0.39) KMT2AMEN1MAPTSMN1; SMN2HTT
SCHEMBL16743476 0.90 KMT2A (0.37) KMT2AMEN1MAPTSMN1; SMN2HTT
SCHEMBL9314454 0.82 KMT2A (0.33) KMT2AMEN1MAPTSMN1; SMN2HTT
SCHEMBL4530562 0.80 RAB9A (0.35) KMT2AMEN1MAPTSMN1; SMN2HTT
SCHEMBL6854230 0.76 KMT2A (0.48) KMT2AMEN1MAPTSMN1; SMN2ESR1
SCHEMBL9006645 0.75 CA9 (0.66) KMT2AMEN1MAPTSMN1; SMN2TDP1
SCHEMBL9315312 0.74 L3MBTL1 (0.45) KMT2AMAPTSMN1; SMN2TDP1L3MBTL1
SCHEMBL1505815 0.73 KIF11 (0.39) KMT2AMEN1SMN1; SMN2ESR1ESR2
SCHEMBL12833375 0.73 KIF11 (0.39) KMT2AMEN1SMN1; SMN2ESR1ESR2
SCHEMBL12833374 0.73 KMT2A (0.43) KMT2AMEN1MAPTSMN1; SMN2TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1996028755-A1 ALIGNMENT LAYER FOR A LIQUID CRYSTAL IN A LIQUID CRYSTAL DISPLAY DEVICE THE DOW CHEMICAL COMPANY (US) 1996-09-19 WO claimed
US-5540997-A POLYMERS FOR ELECTROOPTICAL SWITCHES AND DISPLAY DEVIVES THE DOW CHEMICAL COMPANY (US) 1996-07-30 US claimed
US-9178238-B2 Rubber crack mitigants in polyelectrolyte membranes GM GLOBAL TECHNOLOGY OPERATIONS, LLC (US) 2015-11-03 US disclosed
US-9178238-B2 Rubber crack mitigants in polyelectrolyte membranes GM GLOBAL TECHNOLOGY OPERATIONS, LLC (US) 2015-11-03 US disclosed
US-9040209-B2 Multi-layer polyelectrolyte membranes GM Global Technology Operations LLC (US) 2015-05-26 US disclosed
US-9040209-B2 Multi-layer polyelectrolyte membranes GM Global Technology Operations LLC (US) 2015-05-26 US disclosed
US-20130260279-A1 Rubber Crack Mitigants in Polyelectrolyte Membranes GM GLOBAL TECHNOLOGY OPERATION LLC (US) 2013-10-03 US disclosed
US-20130260279-A1 Rubber Crack Mitigants in Polyelectrolyte Membranes GM GLOBAL TECHNOLOGY OPERATION LLC (US) 2013-10-03 US disclosed
US-20130202987-A1 Multi-Layer Polyelectrolyte Membranes GM GLOBAL TECHNOLOGY OPERATIONS, LLC (US) 2013-08-08 US disclosed
US-20130202987-A1 Multi-Layer Polyelectrolyte Membranes GM GLOBAL TECHNOLOGY OPERATIONS, LLC (US) 2013-08-08 US disclosed
US-20130142946-A1 Electrode With Reduced Mud Cracking Via Mixed Equivalent Weight Ionomers GM Global Technology Operations LLC (US) 2013-06-06 US disclosed
US-20130142946-A1 Electrode With Reduced Mud Cracking Via Mixed Equivalent Weight Ionomers GM Global Technology Operations LLC (US) 2013-06-06 US disclosed
US-5730922-A FLUOROCYCLOBUTANES THE DOW CHEMICAL COMPANY (US) 1998-03-24 US disclosed
WO-1996028755-A1 ALIGNMENT LAYER FOR A LIQUID CRYSTAL IN A LIQUID CRYSTAL DISPLAY DEVICE THE DOW CHEMICAL COMPANY (US) 1996-09-19 WO disclosed
US-5540997-A POLYMERS FOR ELECTROOPTICAL SWITCHES AND DISPLAY DEVIVES THE DOW CHEMICAL COMPANY (US) 1996-07-30 US disclosed
US-5409777-A Protective coatings THE DOW CHEMICAL COMPANY (US) 1995-04-25 US disclosed
US-5246782-A Electronic devices THE DOW CHEMICAL COMPANY (US) 1993-09-21 US disclosed
EP-0490335-A2 Laminates of polymers having perfluorocyclobutane rings and polymers containing perfluorocyclobutane rings THE DOW CHEMICAL COMPANY (US) 1992-06-17 EP disclosed