SCHEMBL6854230

SCHEMBL6854230

FC(F)=C(F)Oc1cccc(OC(F)=C(F)F)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.48
MEN1 O00255 2/20 0.48
NPC1 O15118 1/20 0.39
RAB9A P51151 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
LMNA P02545 2/20 0.38
CYP3A4 P08684 1/20 0.38
ACHE P22303 3/20 0.34
ESR1 P03372 1/20 0.34
ESR2 Q92731 1/20 0.34
MAPT P10636 2/20 0.33
BCHE P06276 2/20 0.33
MITF O75030 1/20 0.33
ALDH1A1 P00352 1/20 0.33
GAA P10253 1/20 0.33
GFER P55789 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
NLRP1 Q9C000 1/20 0.33
NOD2 Q9HC29 1/20 0.33
CA1 P00915 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4865676 0.85 KMT2A (0.47) KMT2AMEN1RAB9ALMNAMAPT
SCHEMBL9315347 0.85 ALDH1A1 (0.50) KMT2AMEN1CYP3A4MAPTMITF
SCHEMBL8641014 0.83 KMT2A (0.35) KMT2AMEN1NPC1RAB9ANPSR1
SCHEMBL2330129 0.82 LTA4H (0.41) MAPTBCHEALDH1A1
SCHEMBL9315304 0.82 PIM1 (0.42) NPC1RAB9ALMNAMAPTSMN1; SMN2
SCHEMBL9549801 0.80 MAPK1 (0.42) KMT2AACHEALDH1A1GAASMN1; SMN2
SCHEMBL8665021 0.80 KMT2A (0.39) KMT2AMEN1NPC1RAB9ALMNA
SCHEMBL16672050 0.79 KMT2A (0.48) KMT2AMEN1NPC1RAB9ANPSR1
SCHEMBL4530562 0.78 RAB9A (0.35) KMT2AMEN1RAB9ALMNAESR1
SCHEMBL14369388 0.78 MTNR1A (0.38) KMT2ANPSR1LMNAALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5730922-A FLUOROCYCLOBUTANES THE DOW CHEMICAL COMPANY (US) 1998-03-24 US claimed
US-5540997-A POLYMERS FOR ELECTROOPTICAL SWITCHES AND DISPLAY DEVIVES THE DOW CHEMICAL COMPANY (US) 1996-07-30 US claimed
EP-1290041-B1 SULFONATED PERFLUOROCYCLOBUTANE ION-CONDUCTING MEMBRANES 3M INNOVATIVE PROPERTIES CO (US) 2004-05-19 EP disclosed
US-6559237-B1 Sulfonated aromatic perfluorocyclobutane polymers meeting a condition selected from: a) the equivalent weight of the polymer is 5000 or less, and b) the proton conductivity of the polymer at 25 degrees C. is 0.01 Siemens per centimeter (S/cm) 3M INNOVATIVE PROPERTIES COMPANY 2003-05-06 US disclosed
US-5730922-A FLUOROCYCLOBUTANES THE DOW CHEMICAL COMPANY (US) 1998-03-24 US disclosed
US-5540997-A POLYMERS FOR ELECTROOPTICAL SWITCHES AND DISPLAY DEVIVES THE DOW CHEMICAL COMPANY (US) 1996-07-30 US disclosed
US-5409777-A Protective coatings THE DOW CHEMICAL COMPANY (US) 1995-04-25 US disclosed
US-5364547-A Lubricants containing perfluorocyclobutane rings THE DOW CHEMICAL COMPANY (US) 1994-11-15 US disclosed
US-5364917-A Perfluorocyclobutane ring-containing polymers THE DOW CHEMICAL COMPANY (US) 1994-11-15 US disclosed
EP-0428708-B1 PROCESS FOR PREPARING A POLYMER HAVING PERFLUOROCYCLOBUTANE RINGS AND POLYMERS CONTAINING PERFLUOROCYCLOBUTANE RINGS DOW CHEMICAL CO (US) 1994-10-05 EP disclosed
EP-0428706-B1 PERFLUOROVINYL COMPOUNDS DOW CHEMICAL CO (US) 1994-07-13 EP disclosed
US-5162468-A Polymers containing perfluorocyclobutane rings THE DOW CHEMICAL COMPANY (US) 1992-11-10 US disclosed
US-5159038-A Flexibility, tensile strength DOW CHEMICAL COMPANY (US) 1992-10-27 US disclosed
EP-0490335-A2 Laminates of polymers having perfluorocyclobutane rings and polymers containing perfluorocyclobutane rings THE DOW CHEMICAL COMPANY (US) 1992-06-17 EP disclosed
US-5037917-A Polymerizing Monomers Containing At Least Two Perfluorovinyl Groups, Then Heating To Form Perfluorocyclobutane Rings THE DOW CHEMICAL COMPANY (US) 1991-08-06 US disclosed
US-5023380-A Monomer for thermoplastic resin THE DOW CHEMICAL COMPANY (US) 1991-06-11 US disclosed
EP-0428708-A1 PROCESS FOR PREPARING A POLYMER HAVING PERFLUOROCYCLOBUTANE RINGS AND POLYMERS CONTAINING PERFLUOROCYCLOBUTANE RINGS. DOW CHEMICAL CO (US) 1991-05-29 EP disclosed
EP-0428706-A1 PERFLUOROVINYL COMPOUNDS. DOW CHEMICAL CO (US) 1991-05-29 EP disclosed
WO-1990015043-A2 PERFLUOROVINYL COMPOUNDS THE DOW CHEMICAL COMPANY (US) 1990-12-13 WO disclosed
WO-1990015082-A1 PROCESS FOR PREPARING A POLYMER HAVING PERFLUOROCYCLOBUTANE RINGS AND POLYMERS CONTAINING PERFLUOROCYCLOBUTANE RINGS THE DOW CHEMICAL COMPANY (US) 1990-12-13 WO disclosed