Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 12/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8641935 | 0.80 | LTA4H (0.61) | LTA4HKMT2A | |
| SCHEMBL8639327 | 0.79 | LTA4H (0.60) | LTA4HLMNANPC1RAB9A | |
| SCHEMBL8641261 | 0.75 | LTA4H (0.56) | LTA4HLMNANPC1RAB9A | |
| SCHEMBL8644158 | 0.74 | LTA4H (0.60) | LTA4HCHRM5 | |
| SCHEMBL8635995 | 0.70 | LTA4H (0.64) | LTA4HLMNANPC1RAB9A | |
| SCHEMBL8640865 | 0.70 | HRH1 (0.50) | LTA4HKDM4ELMNAMEN1ALOX15 | |
| SCHEMBL8639527 | 0.70 | LTA4H (0.49) | LTA4HCHRM5 | |
| SCHEMBL8644360 | 0.69 | LTA4H (0.50) | LTA4HKDM4ENPC1MEN1KMT2A | |
| SCHEMBL8637340 | 0.69 | LTA4H (0.63) | LTA4H | |
| SCHEMBL8635917 | 0.69 | LTA4H (0.64) | LTA4HCHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |