Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 9/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8637391 | 0.74 | LTA4H (0.49) | HRH1ALDH1A1LTA4HCYP1A2CYP2D6 | |
| SCHEMBL8791707 | 0.73 | MEN1 (0.61) | ALDH1A1KDM4EMEN1LMNAKMT2A | |
| SCHEMBL8639520 | 0.71 | HRH1 (0.47) | HRH1SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL8637767 | 0.71 | ALDH1A1 (0.47) | HRH1ALDH1A1SMN1; SMN2LTA4H | |
| SCHEMBL8773746 | 0.70 | LTA4H (0.54) | HRH1ALDH1A1LTA4HKDM4EMEN1 | |
| SCHEMBL8637335 | 0.70 | LTA4H (0.56) | HRH1ALDH1A1LTA4HKDM4EMEN1 | |
| SCHEMBL3560864 | 0.70 | POLB (0.61) | SMN1; SMN2HTTKDM4EMEN1TSHR | |
| SCHEMBL8637394 | 0.70 | LTA4H (0.52) | LTA4HKDM4EMEN1LMNAALOX15 | |
| SCHEMBL5889435 | 0.69 | MEN1 (0.69) | ALDH1A1SMN1; SMN2SLC6A2SLC6A4HTT | |
| SCHEMBL8639322 | 0.69 | SMN1; SMN2 (0.62) | HRH1ALDH1A1SMN1; SMN2LTA4HKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |