Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 2/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29629450 | 0.79 | NPC1 (0.58) | POLBLMNANPC1RAB9AALDH1A1 | |
| SCHEMBL3468799 | 0.79 | NPC1 (0.58) | POLBLMNANPC1RAB9AALDH1A1 | |
| SCHEMBL3641319 | 0.75 | ALDH1A1 (0.45) | POLBLMNAALDH1A1KDM4EHTR2A | |
| SCHEMBL364480 | 0.74 | HTR6 (0.55) | POLBALDH1A1KDM4EHTR2AHTR2C | |
| SCHEMBL15611235 | 0.74 | NPC1 (0.53) | NPC1RAB9AALDH1A1KDM4EMAPT | |
| Formic Acid SCHEMBL5393355 | 0.73 | NPC1 (0.51) | POLBLMNANPC1RAB9AALDH1A1 | |
| SCHEMBL30606406 | 0.73 | BCAT2 (0.53) | NPC1RAB9AALDH1A1KDM4EMAPT | |
| SCHEMBL8997308 | 0.72 | BCAT2 (0.62) | NPC1RAB9AALDH1A1KDM4EHTR2A | |
| SCHEMBL2746856 | 0.72 | HTR6 (0.52) | POLBLMNAALDH1A1KDM4EHPGD | |
| SCHEMBL2468180 | 0.71 | CA2 (0.58) | CA1CA2CA9CA5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0748312-B1 | BICYCLIC CARBAMATES AS LEUKOTRIENE D4 ANTAGONISTS | PFIZER (US) | 1998-07-22 | — | — | EP | claimed |
| EP-0748312-B1 | BICYCLIC CARBAMATES AS LEUKOTRIENE D4 ANTAGONISTS | PFIZER (US) | 1998-07-22 | — | — | EP | disclosed |