SCHEMBL8636796

SCHEMBL8636796

CCOc1ccc(Oc2ccc(OCC=C(Br)Br)c(C(F)(F)F)c2)c(Cl)c1

nearest known ligand 0.42

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
AR P10275 4/20 0.42
MAPT P10636 3/20 0.38
LMNA P02545 2/20 0.38
ATM Q13315 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
SCN9A Q15858 2/20 0.37
ACACB O00763 1/20 0.36
RXRA P19793 1/20 0.35
RXRB P28702 1/20 0.35
RXRG P48443 1/20 0.35
HTR2A P28223 5/20 0.35
SLC6A4 P31645 5/20 0.35
KCNH2 Q12809 4/20 0.35
ESRRA P11474 1/20 0.35
FFAR1 O14842 2/20 0.34
ALDH1A1 P00352 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8638264 0.88 LMNA (0.44) ARMAPTLMNAATML3MBTL1
SCHEMBL8636967 0.87 MAPK1 (0.43) ARMAPTLMNAATML3MBTL1
SCHEMBL8635872 0.82 THRB (0.41) MAPTACACBHTR2ASLC6A4KCNH2
SCHEMBL8632925 0.81 FFAR1 (0.50) HTR2ASLC6A4KCNH2FFAR1
SCHEMBL8634842 0.80 ESRRA (0.50) ARMAPTLMNAATML3MBTL1
SCHEMBL8633636 0.80 THRB (0.36) ARRXRARXRBRXRGHTR2A
SCHEMBL8634753 0.79 AR (0.36) ARMAPTALDH1A1SMN1; SMN2
SCHEMBL8637887 0.79 L3MBTL1 (0.39) ARMAPTLMNAATML3MBTL1
SCHEMBL8632793 0.79 LTA4H (0.43) ARMAPTLMNAATML3MBTL1
SCHEMBL8637041 0.79 AR (0.50) ARHTR2ASLC6A4KCNH2FFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0648729-B1 Dihalopropene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL CO (JP) 1998-07-15 EP disclosed
US-5698702-A INTERMEDIATES FOR INSECTICIDES, ACARICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1997-12-16 US disclosed
US-5530015-A Dihaloprene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient, and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-06-25 US disclosed
EP-0648729-A1 Dihalopropene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1995-04-19 EP disclosed