Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 6/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.40 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8641136 | 0.89 | LTA4H (0.43) | LTA4HRAB9AHPGDPOLBGAA | |
| SCHEMBL8639364 | 0.85 | PPARG (0.44) | LTA4HRAB9AL3MBTL1ALDH1A1NPC1 | |
| SCHEMBL8637374 | 0.82 | LTA4H (0.43) | LTA4HGAAL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL8644119 | 0.75 | PPARG (0.47) | LTA4HL3MBTL1 | |
| SCHEMBL8638403 | 0.72 | LTA4H (0.39) | LTA4HRAB9AHPGDPOLBGAA | |
| SCHEMBL8640502 | 0.70 | LTA4H (0.43) | LTA4HALDH1A1TRPM8PTGS1PTGS2 | |
| SCHEMBL8641132 | 0.69 | LTA4H (0.42) | LTA4HRAB9AHPGDPOLBGAA | |
| SCHEMBL8909018 | 0.69 | LTA4H (0.43) | LTA4HRAB9AHPGDPOLBGAA | |
| SCHEMBL546118 | 0.67 | L3MBTL1 (0.57) | LTA4HRAB9AHPGDPOLBGAA | |
| SCHEMBL10526948 | 0.67 | LTA4H (0.52) | LTA4HRAB9AHPGDPOLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |