Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 5/20 | 0.44 |
| ▸ | PPARA | Q07869 | 5/20 | 0.44 |
| ▸ | LTA4H | P09960 | 6/20 | 0.41 |
| ▸ | ACACB | O00763 | 1/20 | 0.40 |
| ▸ | ACACA | Q13085 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8644119 | 0.89 | PPARG (0.47) | PPARGPPARALTA4HACACBACACA | |
| SCHEMBL8637374 | 0.86 | LTA4H (0.43) | LTA4HL3MBTL1ELANEALDH1A1 | |
| SCHEMBL8638408 | 0.85 | LTA4H (0.44) | LTA4HL3MBTL1NPC1RAB9AALDH1A1 | |
| SCHEMBL8640502 | 0.77 | LTA4H (0.43) | PPARGPPARALTA4HELANEALDH1A1 | |
| SCHEMBL8637712 | 0.74 | PPARG (0.40) | PPARGPPARALTA4HLMNAL3MBTL1 | |
| SCHEMBL8907598 | 0.73 | CYP1A2 (0.47) | PPARGPPARAACACBACACA | |
| SCHEMBL9208923 | 0.71 | SMN1; SMN2 (0.46) | ALDH1A1 | |
| SCHEMBL9208919 | 0.71 | SMN1; SMN2 (0.46) | ALDH1A1 | |
| SCHEMBL17710689 | 0.71 | LMNA (0.56) | PPARGPPARALTA4HACACBACACA | |
| SCHEMBL8639342 | 0.70 | ELANE (0.43) | PPARGPPARALTA4HLMNACA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |