Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 3/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.33 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.32 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8640502 | 0.89 | LTA4H (0.43) | LTA4HPTGS1PTGS2ALDH1A1ELANE | |
| SCHEMBL8639364 | 0.86 | PPARG (0.44) | LTA4HALDH1A1ELANEL3MBTL1 | |
| SCHEMBL8638408 | 0.82 | LTA4H (0.44) | LTA4HPTGS1PTGS2ALDH1A1KDM4E | |
| SCHEMBL8644119 | 0.76 | PPARG (0.47) | LTA4HL3MBTL1 | |
| SCHEMBL8637371 | 0.71 | LTA4H (0.39) | LTA4HPTGS1PTGS2ALDH1A1ELANE | |
| SCHEMBL5684056 | 0.70 | LTA4H (0.48) | LTA4HPTGS1PTGS2ALDH1A1TRPM8 | |
| SCHEMBL8909853 | 0.68 | LTA4H (0.42) | LTA4HPTGS1PTGS2ALDH1A1OPRM1 | |
| SCHEMBL8640499 | 0.68 | LTA4H (0.41) | LTA4HPTGS1PTGS2ALDH1A1ELANE | |
| SCHEMBL1855435 | 0.67 | LTA4H (0.57) | LTA4HALDH1A1SAE1UBA2 | |
| SCHEMBL10391016 | 0.65 | ARG1 (0.36) | TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |